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Articles, Systems/Circuits

Conditional Knock-Out of Vesicular GABA Transporter Gene from Starburst Amacrine Cells Reveals the Contributions of Multiple Synaptic Mechanisms Underlying Direction Selectivity in the Retina

Zhe Pei, Qiang Chen, David Koren, Benno Giammarinaro, Hector Acaron Ledesma and Wei Wei
Journal of Neuroscience 23 September 2015, 35 (38) 13219-13232; DOI: https://doi.org/10.1523/JNEUROSCI.0933-15.2015
Zhe Pei
Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637
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Qiang Chen
Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637
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David Koren
Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637
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Benno Giammarinaro
Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637
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Hector Acaron Ledesma
Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637
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Wei Wei
Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0933-15.2015
PubMed 
26400950
Published By 
Society for Neuroscience
History 
  • Received March 10, 2015
  • Revision received August 17, 2015
  • Accepted August 21, 2015
  • First published September 23, 2015.
  • Version of record published September 23, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/3513219-14$15.00/0

Author Information

  1. Zhe Pei,
  2. Qiang Chen,
  3. David Koren,
  4. Benno Giammarinaro,
  5. Hector Acaron Ledesma, and
  6. Wei Wei
  1. Department of Neurobiology, The University of Chicago, Chicago, Illinois 60637
View Full Text

Author contributions

  1. Author contributions: W.W. designed research; Z.P., Q.C., D.K., B.G., H.A.L., and W.W. performed research; Z.P., Q.C., D.K., B.G., and W.W. analyzed data; Z.P., D.K., and W.W. wrote the paper.

Disclosures

    • Received March 10, 2015.
    • Revision received August 17, 2015.
    • Accepted August 21, 2015.
  • This work was supported by the National Institutes of Health (Grant R01 EY024016), the E. Matilda Ziegler Foundation, Whitehall, Sloan Research, the Karl Kirchgessner Foundation, and the Brinson Foundation. We thank Marla Feller from the University of California at Berkeley for Drd4–GFP mice.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Wei Wei, Department of Neurobiology, The University of Chicago, 947 E. 58th St., MC0928, Chicago, IL 60637. weiw{at}uchicago.edu

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Jan 201817326
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May 201810255
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The Journal of Neuroscience: 35 (38)
Journal of Neuroscience
Vol. 35, Issue 38
23 Sep 2015
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Conditional Knock-Out of Vesicular GABA Transporter Gene from Starburst Amacrine Cells Reveals the Contributions of Multiple Synaptic Mechanisms Underlying Direction Selectivity in the Retina
Zhe Pei, Qiang Chen, David Koren, Benno Giammarinaro, Hector Acaron Ledesma, Wei Wei
Journal of Neuroscience 23 September 2015, 35 (38) 13219-13232; DOI: 10.1523/JNEUROSCI.0933-15.2015

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Conditional Knock-Out of Vesicular GABA Transporter Gene from Starburst Amacrine Cells Reveals the Contributions of Multiple Synaptic Mechanisms Underlying Direction Selectivity in the Retina
Zhe Pei, Qiang Chen, David Koren, Benno Giammarinaro, Hector Acaron Ledesma, Wei Wei
Journal of Neuroscience 23 September 2015, 35 (38) 13219-13232; DOI: 10.1523/JNEUROSCI.0933-15.2015
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Keywords

  • direction selectivity
  • retina
  • starburst amacrine cell
  • synaptic excitation
  • synaptic inhibition
  • vesicular GABA transporter

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