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Articles, Behavioral/Cognitive

Recollection-Related Increases in Functional Connectivity Predict Individual Differences in Memory Accuracy

Danielle R. King, Marianne de Chastelaine, Rachael L. Elward, Tracy H. Wang and Michael D. Rugg
Journal of Neuroscience 28 January 2015, 35 (4) 1763-1772; DOI: https://doi.org/10.1523/JNEUROSCI.3219-14.2015
Danielle R. King
Center for Vital Longevity and School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas 75235
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Marianne de Chastelaine
Center for Vital Longevity and School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas 75235
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Rachael L. Elward
Center for Vital Longevity and School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas 75235
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Tracy H. Wang
Center for Vital Longevity and School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas 75235
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Michael D. Rugg
Center for Vital Longevity and School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Texas 75235
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    Figure 1.

    Regions where the magnitude of the BOLD signal was significantly greater during successful relative to unsuccessful recollection across all three experiments. The main effect of successful retrieval activity across experiments was thresholded at p < 0.001 with a voxel extent of 23 and then masked by the simple effect from each experiment at p < 0.01. Effects are projected onto left and right hemisphere inflated surface caret brains (Caret5; Van Essen et al., 2001) and presented from medial and lateral views. The group peaks of activity within each seed region (AnG, mPFC, Hipp, MTG, PCC; see Materials and Methods) that were used as masks to identify individual subject peaks that were then used to define seed regions are depicted by foci projected onto the lateral and medial surfaces of the caret brains (Experiment 1, magenta; Experiment 2, green; Experiment 3, blue).

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    Figure 2.

    Overlap map of recollection-related activity and connectivity effects. Regions where there was a reliable recollection-related change in activity are depicted in green. Regions where there was a reliable recollection-related change in connectivity with a given seed region are depicted in blue. Regions that demonstrated both a recollection-related change in activity and a recollection-related change in connectivity with a given seed region are depicted in cyan. Main effects across experiments were thresholded at p < 0.001 with a voxel extent of 23 and then masked by the simple effect from each experiment at p < 0.01. Effects are projected onto left and right hemisphere inflated surface caret brains (Caret5; Van Essen et al., 2001) and presented from medial and lateral views.

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    Figure 3.

    Correlations between recollection-related increases in connectivity and recollection accuracy. a, The depicted matrices represent the size of the correlation between seed–target connectivity and behavioral performance across five seeds and three experiments. Within each matrix, each column corresponds to one of the five seed regions for which a PPI analysis was conducted. Each row of the matrix corresponds to one of the 90 target regions defined by the AAL atlas. Colors within each cell of the matrix represent the size of the correlation (Pearson's r) between recollection accuracy and the recollection-related increase in connectivity associated with each seed–target pair. Matrices correspond to Experiments 1 (top), 2 (middle), and 3 (bottom). Matrices on the left and right are identical except that those on the left are coded continuously, whereas those on the right are thresholded at r > 0.41 (p < 0.05 for the experiment with the smallest sample size). b, Bar graphs represent the average correlation between recollection-related increases in connectivity and recollection accuracy for each seed region (left), and the proportion of brain regions where the change in connectivity correlated with recollection accuracy with an effect size of r > 0.41 (right). Error bars reflect the SEM; †p < 0.05, *p < 0.01, **p < 0.001.

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    Figure 4.

    Heat maps representing, for each of the 90 ROIs, the number of experiments for which there was a significant relationship between connectivity change and recollection accuracy. Borders of the 90 cortical, striatal, and thalamic regions defined by the AAL atlas are projected onto left and right hemisphere inflated surface caret brains (Caret5; Van Essen et al., 2001) which are presented from medial and lateral views. For each seed, target regions where the correlation between connectivity and accuracy was significant in all three experiments are presented in red; regions where this relationship was significant in two of three experiments are presented in orange; regions where this relationship was significant in only one of three experiments are presented in yellow, and regions where this relationship was not significant in any of the three experiments are presented in white. Correlations were considered statistically significant if the correlation coefficient (Pearson's r) exceeded r > 0.41. This effect size was chosen because it corresponds to the smallest statistically significant value (p < 0.05, two-tailed) in the experiment with the smallest sample size.

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The Journal of Neuroscience: 35 (4)
Journal of Neuroscience
Vol. 35, Issue 4
28 Jan 2015
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Recollection-Related Increases in Functional Connectivity Predict Individual Differences in Memory Accuracy
Danielle R. King, Marianne de Chastelaine, Rachael L. Elward, Tracy H. Wang, Michael D. Rugg
Journal of Neuroscience 28 January 2015, 35 (4) 1763-1772; DOI: 10.1523/JNEUROSCI.3219-14.2015

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Recollection-Related Increases in Functional Connectivity Predict Individual Differences in Memory Accuracy
Danielle R. King, Marianne de Chastelaine, Rachael L. Elward, Tracy H. Wang, Michael D. Rugg
Journal of Neuroscience 28 January 2015, 35 (4) 1763-1772; DOI: 10.1523/JNEUROSCI.3219-14.2015
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Keywords

  • angular gyrus
  • episodic memory
  • fMRI
  • functional connectivity
  • hippocampus
  • recollection

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