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Articles, Behavioral/Cognitive

Morphometric and Histologic Substrates of Cingulate Integrity in Elders with Exceptional Memory Capacity

Tamar Gefen, Melanie Peterson, Steven T. Papastefan, Adam Martersteck, Kristen Whitney, Alfred Rademaker, Eileen H. Bigio, Sandra Weintraub, Emily Rogalski, M.-Marsel Mesulam and Changiz Geula
Journal of Neuroscience 28 January 2015, 35 (4) 1781-1791; https://doi.org/10.1523/JNEUROSCI.2998-14.2015
Tamar Gefen
1Cognitive Neurology and Alzheimer's Disease Center,
2Department of Psychiatry and Behavioral Sciences,
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Melanie Peterson
1Cognitive Neurology and Alzheimer's Disease Center,
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Steven T. Papastefan
1Cognitive Neurology and Alzheimer's Disease Center,
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Adam Martersteck
1Cognitive Neurology and Alzheimer's Disease Center,
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Kristen Whitney
1Cognitive Neurology and Alzheimer's Disease Center,
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Alfred Rademaker
1Cognitive Neurology and Alzheimer's Disease Center,
3Department of Preventive Medicine,
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Eileen H. Bigio
1Cognitive Neurology and Alzheimer's Disease Center,
4Department of Pathology, and
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Sandra Weintraub
1Cognitive Neurology and Alzheimer's Disease Center,
2Department of Psychiatry and Behavioral Sciences,
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Emily Rogalski
1Cognitive Neurology and Alzheimer's Disease Center,
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M.-Marsel Mesulam
1Cognitive Neurology and Alzheimer's Disease Center,
5Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611
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Changiz Geula
1Cognitive Neurology and Alzheimer's Disease Center,
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Abstract

This human study is based on an established cohort of “SuperAgers,” 80+-year-old individuals with episodic memory function at a level equal to, or better than, individuals 20–30 years younger. A preliminary investigation using structural brain imaging revealed a region of anterior cingulate cortex that was thicker in SuperAgers compared with healthy 50- to 65-year-olds. Here, we investigated the in vivo structural features of cingulate cortex in a larger sample of SuperAgers and conducted a histologic analysis of this region in postmortem specimens. A region-of-interest MRI structural analysis found cingulate cortex to be thinner in cognitively average 80+ year olds (n = 21) than in the healthy middle-aged group (n = 18). A region of the anterior cingulate cortex in the right hemisphere displayed greater thickness in SuperAgers (n = 31) compared with cognitively average 80+ year olds and also to the much younger healthy 50–60 year olds (p < 0.01). Postmortem investigations were conducted in the cingulate cortex in five SuperAgers, five cognitively average elderly individuals, and five individuals with amnestic mild cognitive impairment. Compared with other subject groups, SuperAgers showed a lower frequency of Alzheimer-type neurofibrillary tangles (p < 0.05). There were no differences in total neuronal size or count between subject groups. Interestingly, relative to total neuronal packing density, there was a higher density of von Economo neurons (p < 0.05), particularly in anterior cingulate regions of SuperAgers. These findings suggest that reduced vulnerability to the age-related emergence of Alzheimer pathology and higher von Economo neuron density in anterior cingulate cortex may represent biological correlates of high memory capacity in advanced old age.

  • aging
  • Alzheimer's pathology
  • cingulate cortex
  • cognition
  • histology
  • structural MRI
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The Journal of Neuroscience: 35 (4)
Journal of Neuroscience
Vol. 35, Issue 4
28 Jan 2015
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Morphometric and Histologic Substrates of Cingulate Integrity in Elders with Exceptional Memory Capacity
Tamar Gefen, Melanie Peterson, Steven T. Papastefan, Adam Martersteck, Kristen Whitney, Alfred Rademaker, Eileen H. Bigio, Sandra Weintraub, Emily Rogalski, M.-Marsel Mesulam, Changiz Geula
Journal of Neuroscience 28 January 2015, 35 (4) 1781-1791; DOI: 10.1523/JNEUROSCI.2998-14.2015

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Morphometric and Histologic Substrates of Cingulate Integrity in Elders with Exceptional Memory Capacity
Tamar Gefen, Melanie Peterson, Steven T. Papastefan, Adam Martersteck, Kristen Whitney, Alfred Rademaker, Eileen H. Bigio, Sandra Weintraub, Emily Rogalski, M.-Marsel Mesulam, Changiz Geula
Journal of Neuroscience 28 January 2015, 35 (4) 1781-1791; DOI: 10.1523/JNEUROSCI.2998-14.2015
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Keywords

  • aging
  • Alzheimer's pathology
  • cingulate cortex
  • cognition
  • histology
  • structural MRI

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