Cover legend: This image shows axons (neurofilament, green), pallidal cells (Nkx2-1, red), and cell nuclei (blue) in a coronal brain section from an embryonic day 17, Frizzled3 knock-out mouse. In Frizzled3 knock-out mice, the axons of striatal projection neurons fail to extend along the anterior–posterior axis of the striatum, and many do not extend beyond the globus pallidus, suggesting Frizzled3 has a role in striatal axon guidance. For more information, see the article by Morello et al. (pages 14205–14219).