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Articles, Systems/Circuits

Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala Norepinephrine Systems that Promote PTSD-Like Startle Abnormalities

Abha K. Rajbhandari, Brian A. Baldo and Vaishali P. Bakshi
Journal of Neuroscience 21 October 2015, 35 (42) 14270-14285; DOI: https://doi.org/10.1523/JNEUROSCI.5080-14.2015
Abha K. Rajbhandari
2Neuroscience Training Program, University of Wisconsin-Madison, Madison, Wisconsin 53719
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Brian A. Baldo
1Department of Psychiatry and
2Neuroscience Training Program, University of Wisconsin-Madison, Madison, Wisconsin 53719
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Vaishali P. Bakshi
1Department of Psychiatry and
2Neuroscience Training Program, University of Wisconsin-Madison, Madison, Wisconsin 53719
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5080-14.2015
PubMed 
26490866
Published By 
Society for Neuroscience
History 
  • Received December 15, 2014
  • Revision received June 6, 2015
  • Accepted July 10, 2015
  • First published October 21, 2015.
  • Version of record published October 21, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/3514270-16$15.00/0

Author Information

  1. Abha K. Rajbhandari2,
  2. Brian A. Baldo1,2,*, and
  3. Vaishali P. Bakshi1,2,*
  1. 1Department of Psychiatry and
  2. 2Neuroscience Training Program, University of Wisconsin-Madison, Madison, Wisconsin 53719
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Author contributions

  1. Author contributions: B.A.B. and V.P.B. designed research; A.K.R. performed research; A.K.R., B.A.B., and V.P.B. analyzed data; A.K.R., B.A.B., and V.P.B. wrote the paper.

  2. ↵*B.A.B. and V.P.B. contributed equally to this work.

Disclosures

    • Received December 15, 2014.
    • Revision received June 6, 2015.
    • Accepted July 10, 2015.
  • This work was supported by Grants R01-MH-075980 (to V.P.B.) and T32 GM007507, and a NARSAD Young Investigator Award (to V.P.B.). We thank Dr. Karla Knobel for assistance with the fluorescence images.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either Dr. Vaishali P. Bakshi or Dr. Brian A. Baldo, Department of Psychiatry, UW-SMPH, Wisconsin Psychiatric Institute and Clinics, 6001 Research Park Boulevard, Madison, WI 53719, vbakshi{at}wisc.edu or babaldo{at}wisc.edu

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Jan 2018515024
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Apr 2021292922
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Total 2022211420245
Jan 2023146314
Total 2023146314
Total136620991100
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The Journal of Neuroscience: 35 (42)
Journal of Neuroscience
Vol. 35, Issue 42
21 Oct 2015
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Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala Norepinephrine Systems that Promote PTSD-Like Startle Abnormalities
Abha K. Rajbhandari, Brian A. Baldo, Vaishali P. Bakshi
Journal of Neuroscience 21 October 2015, 35 (42) 14270-14285; DOI: 10.1523/JNEUROSCI.5080-14.2015

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Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala Norepinephrine Systems that Promote PTSD-Like Startle Abnormalities
Abha K. Rajbhandari, Brian A. Baldo, Vaishali P. Bakshi
Journal of Neuroscience 21 October 2015, 35 (42) 14270-14285; DOI: 10.1523/JNEUROSCI.5080-14.2015
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Keywords

  • corticotropin-releasing factor
  • corticotropin-releasing hormone
  • noradrenergic
  • prepulse inhibition
  • schizophrenia
  • sensorimotor gating

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