Article Information
- Received February 16, 2015
- Revision received August 31, 2015
- Accepted September 8, 2015
- First published October 21, 2015.
- Version of record published October 21, 2015.
Author Information
- Angela M. Jablonski1,
- Todd Lamitina4,
- Nicole F. Liachko5,
- Mariangela Sabatella6,
- Jiayin Lu7,
- Lei Zhang2,
- Lyle W. Ostrow8,
- Preetika Gupta1,
- Chia-Yen Wu2,
- Shachee Doshi1,
- Jelena Mojsilovic-Petrovic2,
- Hannes Lans6,
- Jiou Wang7,
- Brian Kraemer6, and
- Robert G. Kalb2,3
- 1Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104,
- 2Department of Pediatrics, Division of Neurology, Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104,
- 3Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104,
- 4Department of Pediatrics and Cell Biology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213,
- 5Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Department of Medicine, University of Washington, Seattle, Washington 98195,
- 6Department of Genetics, Erasmus Medical Centre, Cancer Genomics Institute, Rotterdam 3015 CN, The Netherlands,
- 7Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and
- 8Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Author contributions
Author contributions: A.M.J., T.L., N.F.L., M.S., J.L., L.Z., L.W.O., C.-Y.W., H.L., J.W., B.K., and R.G.K. designed research; A.M.J., T.L., N.F.L., M.S., J.L., L.Z., P.G., C.-Y.W., S.D., H.L., J.W., and B.K. performed research; A.M.J., L.W.O., and J.M.-P. contributed unpublished reagents/analytic tools; A.M.J., T.L., N.F.L., M.S., J.L., P.G., C.-Y.W., S.D., H.L., J.W., B.K., and R.G.K. analyzed data; A.M.J. and R.G.K. wrote the paper.
Disclosures
- Received February 16, 2015.
- Revision received August 31, 2015.
- Accepted September 8, 2015.
This work was supported by NIH Grants R01-NS052325 and R21-NS077909 to R.G.K., F31-NS07726 to A.M.J., and FP7 Marie Curie International Training Network Address 316390 to M.S. The RAD-23 fosmid was obtained from the C. elegans TransgeneOme project. Some strains were provided by the Caenorhabditis Genetics Center, which is funded by National Institutes of Health Office of Research Infrastructure Programs P40-OD010440, and the National Bioresource Project for the Nematode. We thank Ulrich Hartl for the CPY*-GFP plasmid; Steven Grossman for the RAD-23 plasmids; Johns Ravits and Jeff Rothstein for providing human tissue; Maria Lim, Elizabeth Morton, Zissimos Mourelatos, and Predrag Krajacic for assistance; the Target ALS Human Postmortem Tissue Core for providing postmortem tissue samples; and Harry Ischiropolous, Kelly Jordan-Sciutto, Alice Chen-Plotkin, and Raymond Roos for guidance and helpful discussion.
The authors declare no competing financial interests.
- Correspondence should be addressed to Dr. Robert G. Kalb, Research Institute, Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104. kalb{at}email.chop.edu
