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Articles, Neurobiology of Disease

Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance

Angela M. Jablonski, Todd Lamitina, Nicole F. Liachko, Mariangela Sabatella, Jiayin Lu, Lei Zhang, Lyle W. Ostrow, Preetika Gupta, Chia-Yen Wu, Shachee Doshi, Jelena Mojsilovic-Petrovic, Hannes Lans, Jiou Wang, Brian Kraemer and Robert G. Kalb
Journal of Neuroscience 21 October 2015, 35 (42) 14286-14306; https://doi.org/10.1523/JNEUROSCI.0642-15.2015
Angela M. Jablonski
1Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104,
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Todd Lamitina
4Department of Pediatrics and Cell Biology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213,
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Nicole F. Liachko
5Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Department of Medicine, University of Washington, Seattle, Washington 98195,
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Mariangela Sabatella
6Department of Genetics, Erasmus Medical Centre, Cancer Genomics Institute, Rotterdam 3015 CN, The Netherlands,
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  • ORCID record for Mariangela Sabatella
Jiayin Lu
7Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and
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Lei Zhang
2Department of Pediatrics, Division of Neurology, Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104,
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Lyle W. Ostrow
8Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
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Preetika Gupta
1Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104,
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Chia-Yen Wu
2Department of Pediatrics, Division of Neurology, Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104,
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Shachee Doshi
1Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104,
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Jelena Mojsilovic-Petrovic
2Department of Pediatrics, Division of Neurology, Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104,
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Hannes Lans
6Department of Genetics, Erasmus Medical Centre, Cancer Genomics Institute, Rotterdam 3015 CN, The Netherlands,
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Jiou Wang
7Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and
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Brian Kraemer
6Department of Genetics, Erasmus Medical Centre, Cancer Genomics Institute, Rotterdam 3015 CN, The Netherlands,
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Robert G. Kalb
2Department of Pediatrics, Division of Neurology, Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104,
3Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104,
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The Journal of Neuroscience: 35 (42)
Journal of Neuroscience
Vol. 35, Issue 42
21 Oct 2015
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Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance
Angela M. Jablonski, Todd Lamitina, Nicole F. Liachko, Mariangela Sabatella, Jiayin Lu, Lei Zhang, Lyle W. Ostrow, Preetika Gupta, Chia-Yen Wu, Shachee Doshi, Jelena Mojsilovic-Petrovic, Hannes Lans, Jiou Wang, Brian Kraemer, Robert G. Kalb
Journal of Neuroscience 21 October 2015, 35 (42) 14286-14306; DOI: 10.1523/JNEUROSCI.0642-15.2015

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Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance
Angela M. Jablonski, Todd Lamitina, Nicole F. Liachko, Mariangela Sabatella, Jiayin Lu, Lei Zhang, Lyle W. Ostrow, Preetika Gupta, Chia-Yen Wu, Shachee Doshi, Jelena Mojsilovic-Petrovic, Hannes Lans, Jiou Wang, Brian Kraemer, Robert G. Kalb
Journal of Neuroscience 21 October 2015, 35 (42) 14286-14306; DOI: 10.1523/JNEUROSCI.0642-15.2015
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Keywords

  • aging
  • ALS
  • motor neuron disease
  • neurodegeneration
  • proteotoxicity
  • RAD-23

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