Cover legend: An image of mouse layer 5b neocortical neurons double immunolabeled for Kv2.1 (green) and Kv2.2 (red), and with Hoechst (blue) staining to label nuclei. Image reveals cell-specific labeling for these two highly related but distinctly regulated Kv channels in layer 5b. For more information, see the article by Bishop et al. (pages 14922–14942).