Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE
PreviousNext
Featured ArticleArticles, Development/Plasticity/Repair

Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation

Pamela J. Yao, Ronald S. Petralia, Carolyn Ott, Ya-Xian Wang, Jennifer Lippincott-Schwartz and Mark P. Mattson
Journal of Neuroscience 9 December 2015, 35 (49) 16126-16141; https://doi.org/10.1523/JNEUROSCI.1360-15.2015
Pamela J. Yao
1Laboratory of Neurosciences, National Institute on Aging–National Institutes of Health, Baltimore, Maryland 21224,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ronald S. Petralia
2Advanced Imaging Core, National Institute on Deafness and Other Communication Disorders (NIDCD)–National Institutes of Health, Bethesda, Maryland 20892, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carolyn Ott
3Cell Biology and Metabolism Program, National Institute of Child Health and Human Development–National Institutes of Health, Bethesda, Maryland 20892
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ya-Xian Wang
2Advanced Imaging Core, National Institute on Deafness and Other Communication Disorders (NIDCD)–National Institutes of Health, Bethesda, Maryland 20892, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jennifer Lippincott-Schwartz
3Cell Biology and Metabolism Program, National Institute of Child Health and Human Development–National Institutes of Health, Bethesda, Maryland 20892
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark P. Mattson
1Laboratory of Neurosciences, National Institute on Aging–National Institutes of Health, Baltimore, Maryland 21224,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1360-15.2015
PubMed 
26658865
Published By 
Society for Neuroscience
History 
  • Received April 9, 2015
  • Revision received October 22, 2015
  • Accepted October 29, 2015
  • First published December 9, 2015.
  • Version of record published December 9, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/3516126-16$15.00/0

Author Information

  1. Pamela J. Yao1,
  2. Ronald S. Petralia2,*,
  3. Carolyn Ott3,*,
  4. Ya-Xian Wang2,
  5. Jennifer Lippincott-Schwartz3, and
  6. Mark P. Mattson1
  1. 1Laboratory of Neurosciences, National Institute on Aging–National Institutes of Health, Baltimore, Maryland 21224,
  2. 2Advanced Imaging Core, National Institute on Deafness and Other Communication Disorders (NIDCD)–National Institutes of Health, Bethesda, Maryland 20892, and
  3. 3Cell Biology and Metabolism Program, National Institute of Child Health and Human Development–National Institutes of Health, Bethesda, Maryland 20892
View Full Text

Author contributions

  1. Author contributions: P.J.Y., R.S.P., C.O., J.L.-S., and M.P.M. designed research; P.J.Y., R.S.P., C.O., and Y.-X.W. performed research; C.O. and J.L.-S. contributed unpublished reagents/analytic tools; P.J.Y., R.S.P., C.O., and M.P.M. analyzed data; P.J.Y. wrote the paper.

  2. ↵*R.S.P. and C.O. contributed equally to this work.

Disclosures

    • Received April 9, 2015.
    • Revision received October 22, 2015.
    • Accepted October 29, 2015.
  • This work was supported by the Intramural Research Programs of the National Institute on Aging–National Institutes of Health (NIH), the National Institute on Deafness and Other Communication Disorders (NIDCD)–NIH, and the National Institute of Child Health and Human Development–NIH. The facility code for the Advanced Imaging Core of the NIDCD–NIH is ZIC DC000081-03. We thank Emmette R. Hutchison for assistance with qRT-PCR; Peisu Zhang and Ryan Wu for lentiviral production; Fred E. Indig for confocal imaging; James K. Chen for the Glix8::EGFP construct and Shh-N-expressing HEK 293 cells; James Briscoe for PAP-A and Gli3N constructs; and John Lander for profilin1 constructs.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Pamela J. Yao, Laboratory of Neurosciences, NIA/NIH Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224. yaopa{at}grc.nia.nih.gov

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-06-13
to
E.g., 2025-06-13

Article usage: January 2018 to May 2025

AbstractFullPdf
Jan 201814269
Feb 20189279
Mar 201823716
Apr 2018124817
May 20187526
Jun 201854515
Jul 201854014
Aug 20184386
Sep 2018103412
Oct 20183356
Nov 201813317
Dec 201842210
Total 201888435127
Jan 20193306
Feb 201992910
Mar 201962617
Apr 201992717
May 201911269
Jun 20197379
Jul 201922012
Aug 20193238
Oct 2019611818
Nov 201944015
Dec 201914269
Total 201974402130
Jan 202010288
Feb 202042811
Mar 202082917
May 202032529
Jun 202032615
Jul 20200238
Aug 20201126
Sep 20203268
Oct 20203288
Nov 202072415
Dec 2020164214
Total 202058291139
Jan 20218237
Feb 202112511
Mar 202163321
Apr 202151923
May 202153519
Jun 202152014
Jul 202131611
Aug 20211126
Sep 20213229
Oct 202182131
Nov 202161523
Dec 202151613
Total 202156257188
Jan 2022112421
Feb 202222513
Mar 202293927
Apr 202262517
May 202232118
Jun 2022112117
Jul 20226149
Aug 202231711
Sep 202232711
Oct 202254317
Nov 2022137
Dec 2022281
Total 202262267169
Jan 202344318
Feb 20232204
Mar 202312014
Apr 202323012
May 202353314
Jun 20233155
Jul 202331611
Aug 202311417
Sep 20233165
Oct 20236195
Nov 2023313315
Dec 20232227
Total 202335381127
Jan 202418446
Feb 202463914
Mar 202402512
Apr 2024419310
May 202413518
Jun 202452511
Jul 202423129
Aug 202463417
Sep 202442115
Oct 202422719
Nov 202423117
Dec 202482929
Total 202458534197
Jan 202562421
Feb 20254278
Mar 202517286
Apr 202542612
May 2025193
Total 20253211450
Total46326811127
Back to top

In this issue

The Journal of Neuroscience: 35 (49)
Journal of Neuroscience
Vol. 35, Issue 49
9 Dec 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Advertising (PDF)
  • Ed Board (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation
Pamela J. Yao, Ronald S. Petralia, Carolyn Ott, Ya-Xian Wang, Jennifer Lippincott-Schwartz, Mark P. Mattson
Journal of Neuroscience 9 December 2015, 35 (49) 16126-16141; DOI: 10.1523/JNEUROSCI.1360-15.2015

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation
Pamela J. Yao, Ronald S. Petralia, Carolyn Ott, Ya-Xian Wang, Jennifer Lippincott-Schwartz, Mark P. Mattson
Journal of Neuroscience 9 December 2015, 35 (49) 16126-16141; DOI: 10.1523/JNEUROSCI.1360-15.2015
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • axon
  • hippocampal neuron
  • primary cilium
  • profilin 1
  • Smoothened
  • Sonic hedgehog

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Articles

  • Memory Retrieval Has a Dynamic Influence on the Maintenance Mechanisms That Are Sensitive to ζ-Inhibitory Peptide (ZIP)
  • Neurophysiological Evidence for a Cortical Contribution to the Wakefulness-Related Drive to Breathe Explaining Hypocapnia-Resistant Ventilation in Humans
  • Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase
Show more Articles

Development/Plasticity/Repair

  • Acoustic Enrichment Prevents Early Life Stress-Induced Disruptions in Sound Azimuth Processing
  • Concentration-Dependent Bidirectional Modification of Evoked Synaptic Transmission by Gadolinium and Adverse Effects of Gadolinium-Based Contrast Agent
  • Stereotyped spatiotemporal dynamics of spontaneous activity in visual cortex prior to eye-opening
Show more Development/Plasticity/Repair
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Accessibility
(JNeurosci logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.