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Articles, Systems/Circuits

Antagonism of PACAP or Microglia Function Worsens the Cardiovascular Consequences of Kainic-Acid-Induced Seizures in Rats

Amol M. Bhandare, Suja Mohammed, Paul M. Pilowsky and Melissa M.J. Farnham
Journal of Neuroscience 4 February 2015, 35 (5) 2191-2199; https://doi.org/10.1523/JNEUROSCI.4058-14.2015
Amol M. Bhandare
1Australian School of Advanced Medicine, Macquarie University, Sydney, 2109 New South Wales, Australia,
2The Heart Research Institute, 2042 New South Wales, Australia, and
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Suja Mohammed
2The Heart Research Institute, 2042 New South Wales, Australia, and
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Paul M. Pilowsky
2The Heart Research Institute, 2042 New South Wales, Australia, and
3Department of Physiology, University of Sydney, Sydney, 2006 New South Wales, Australia
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Melissa M.J. Farnham
1Australian School of Advanced Medicine, Macquarie University, Sydney, 2109 New South Wales, Australia,
2The Heart Research Institute, 2042 New South Wales, Australia, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4058-14.2015
PubMed 
25653374
Published By 
Society for Neuroscience
History 
  • Received September 30, 2014
  • Revision received December 18, 2014
  • Accepted December 23, 2014
  • First published February 4, 2015.
  • Version of record published February 4, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/352191-09$15.00/0

Author Information

  1. Amol M. Bhandare1,2,
  2. Suja Mohammed2,
  3. Paul M. Pilowsky2,3, and
  4. Melissa M.J. Farnham1,2
  1. 1Australian School of Advanced Medicine, Macquarie University, Sydney, 2109 New South Wales, Australia,
  2. 2The Heart Research Institute, 2042 New South Wales, Australia, and
  3. 3Department of Physiology, University of Sydney, Sydney, 2006 New South Wales, Australia
View Full Text

Author contributions

  1. Author contributions: A.M.B., P.M.P., and M.M.J.F. designed research; A.M.B., S.M., and M.M.J.F. performed research; A.M.B., S.M., P.M.P., and M.M.J.F. contributed unpublished reagents/analytic tools; A.M.B., P.M.P., and M.M.J.F. analyzed data; A.M.B., P.M.P., and M.M.J.F. wrote the paper.

Disclosures

    • Received September 30, 2014.
    • Revision received December 18, 2014.
    • Accepted December 23, 2014.
  • This work was supported by the Australian Research Council (Discovery Early Career Researcher Award DE120100992), the National Health and Medical Research Council of Australia (Grant 1065485 and Fellowship 1024489), and the Heart Research Institute. A.M.B. is supported by an International Macquarie University Research Excellence Scholarship (No. 2012219).

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Paul M. Pilowsky, The Heart Research Institute, 7 Eliza Street, Sydney, 2042 New South Wales, Australia. paul.pilowsky{at}hri.org.au

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Total 2025194308168
Total7501729880
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The Journal of Neuroscience: 35 (5)
Journal of Neuroscience
Vol. 35, Issue 5
4 Feb 2015
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Antagonism of PACAP or Microglia Function Worsens the Cardiovascular Consequences of Kainic-Acid-Induced Seizures in Rats
Amol M. Bhandare, Suja Mohammed, Paul M. Pilowsky, Melissa M.J. Farnham
Journal of Neuroscience 4 February 2015, 35 (5) 2191-2199; DOI: 10.1523/JNEUROSCI.4058-14.2015

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Antagonism of PACAP or Microglia Function Worsens the Cardiovascular Consequences of Kainic-Acid-Induced Seizures in Rats
Amol M. Bhandare, Suja Mohammed, Paul M. Pilowsky, Melissa M.J. Farnham
Journal of Neuroscience 4 February 2015, 35 (5) 2191-2199; DOI: 10.1523/JNEUROSCI.4058-14.2015
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Keywords

  • kainic acid
  • microglia
  • PACAP
  • seizure
  • SUDEP
  • sympathetic nerve activity

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