Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

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¹Gladstone Institute of Neurological Disease, San Francisco, California 94158,
²Department of Neurology, University of California, San Francisco, California 94158,
³Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390,
⁴Departments of Neurosciences and Pathology, University of California, San Diego, San Diego, California 92093, and
⁵Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118

Author contributions: D.B.D., C.R.A., and L.M. designed research; D.B.D., L.Z., P.E.S., K.W., L.B., E.J., K.H., G.-Q.Y., D.K., A.B., and E.M. performed research; D.B.D., M.K.-o., and L.M. contributed unpublished reagents/analytic tools; D.B.D., L.Z., P.E.S., K.W., L.B., E.J., G.-Q.Y., D.K., A.B., M.K.-o., E.M., and L.M. analyzed data; D.B.D. and L.M. wrote the paper.

This work was supported by NIH Grants NS041787, NS065780, and NS088532 (L.M.), AG034531 (D.B.D.), AG18440 and AG010435 (E.M.), AG000001 (C.R.A.), AG019712 (M.K.), a MetLife/AFAR Award (L.M.), gifts from the S. D. Bechtel Jr Foundation (L.M.), the Weeks-Coulter Foundation (D.B.D.), the Bakar Family Foundation (D.B.D.), and NIH National Center for Research Resources Grant RR18938-01 to the Gladstone Institutes. We thank Drs Gerald Hart and Peter Davies for tau antibodies; Elan Pharmaceuticals for Aβ antibodies; X. Wang, W. Guo, C. Wang, and S. Cheung for technical assistance; J. Palop, M. Morris, J. Harris, M. Cisse, and B. Djukic for discussions; K. Eilertson for assistance with statistics; and M. Dela Cruz for administrative support.
Correspondence should be addressed to either of the following: Dena Dubal, 675 Nelson Rising Line, San Francisco, CA 94158, dena.dubal{at}ucsf.edu; or Lennart Mucke, 1650 Owens Street, San Francisco, CA 94158. lmucke{at}gladstone.ucsf.edu

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