Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE
PreviousNext
Articles, Neurobiology of Disease

Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

Dena B. Dubal, Lei Zhu, Pascal E. Sanchez, Kurtresha Worden, Lauren Broestl, Erik Johnson, Kaitlyn Ho, Gui-Qiu Yu, Daniel Kim, Alexander Betourne, Makoto Kuro-o, Eliezer Masliah, Carmela R. Abraham and Lennart Mucke
Journal of Neuroscience 11 February 2015, 35 (6) 2358-2371; DOI: https://doi.org/10.1523/JNEUROSCI.5791-12.2015
Dena B. Dubal
1Gladstone Institute of Neurological Disease, San Francisco, California 94158,
2Department of Neurology, University of California, San Francisco, California 94158,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lei Zhu
1Gladstone Institute of Neurological Disease, San Francisco, California 94158,
2Department of Neurology, University of California, San Francisco, California 94158,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pascal E. Sanchez
1Gladstone Institute of Neurological Disease, San Francisco, California 94158,
2Department of Neurology, University of California, San Francisco, California 94158,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kurtresha Worden
1Gladstone Institute of Neurological Disease, San Francisco, California 94158,
2Department of Neurology, University of California, San Francisco, California 94158,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kurtresha Worden
Lauren Broestl
2Department of Neurology, University of California, San Francisco, California 94158,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Erik Johnson
1Gladstone Institute of Neurological Disease, San Francisco, California 94158,
2Department of Neurology, University of California, San Francisco, California 94158,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kaitlyn Ho
1Gladstone Institute of Neurological Disease, San Francisco, California 94158,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gui-Qiu Yu
1Gladstone Institute of Neurological Disease, San Francisco, California 94158,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel Kim
1Gladstone Institute of Neurological Disease, San Francisco, California 94158,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexander Betourne
2Department of Neurology, University of California, San Francisco, California 94158,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Makoto Kuro-o
3Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eliezer Masliah
4Departments of Neurosciences and Pathology, University of California, San Diego, San Diego, California 92093, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carmela R. Abraham
5Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lennart Mucke
1Gladstone Institute of Neurological Disease, San Francisco, California 94158,
2Department of Neurology, University of California, San Francisco, California 94158,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.5791-12.2015
PubMed 
25673831
Published By 
Society for Neuroscience
History 
  • Received December 18, 2012
  • Revision received December 6, 2014
  • Accepted December 21, 2014
  • First published February 11, 2015.
  • Version of record published February 11, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/352358-14$15.00/0

Author Information

  1. Dena B. Dubal1,2,
  2. Lei Zhu1,2,
  3. Pascal E. Sanchez1,2,
  4. Kurtresha Worden1,2,
  5. Lauren Broestl2,
  6. Erik Johnson1,2,
  7. Kaitlyn Ho1,
  8. Gui-Qiu Yu1,
  9. Daniel Kim1,
  10. Alexander Betourne2,
  11. Makoto Kuro-o3,
  12. Eliezer Masliah4,
  13. Carmela R. Abraham5, and
  14. Lennart Mucke1,2
  1. 1Gladstone Institute of Neurological Disease, San Francisco, California 94158,
  2. 2Department of Neurology, University of California, San Francisco, California 94158,
  3. 3Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390,
  4. 4Departments of Neurosciences and Pathology, University of California, San Diego, San Diego, California 92093, and
  5. 5Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118
View Full Text

Author contributions

  1. Author contributions: D.B.D., C.R.A., and L.M. designed research; D.B.D., L.Z., P.E.S., K.W., L.B., E.J., K.H., G.-Q.Y., D.K., A.B., and E.M. performed research; D.B.D., M.K.-o., and L.M. contributed unpublished reagents/analytic tools; D.B.D., L.Z., P.E.S., K.W., L.B., E.J., G.-Q.Y., D.K., A.B., M.K.-o., E.M., and L.M. analyzed data; D.B.D. and L.M. wrote the paper.

Disclosures

    • Received December 18, 2012.
    • Revision received December 6, 2014.
    • Accepted December 21, 2014.
  • This work was supported by NIH Grants NS041787, NS065780, and NS088532 (L.M.), AG034531 (D.B.D.), AG18440 and AG010435 (E.M.), AG000001 (C.R.A.), AG019712 (M.K.), a MetLife/AFAR Award (L.M.), gifts from the S. D. Bechtel Jr Foundation (L.M.), the Weeks-Coulter Foundation (D.B.D.), the Bakar Family Foundation (D.B.D.), and NIH National Center for Research Resources Grant RR18938-01 to the Gladstone Institutes. We thank Drs Gerald Hart and Peter Davies for tau antibodies; Elan Pharmaceuticals for Aβ antibodies; X. Wang, W. Guo, C. Wang, and S. Cheung for technical assistance; J. Palop, M. Morris, J. Harris, M. Cisse, and B. Djukic for discussions; K. Eilertson for assistance with statistics; and M. Dela Cruz for administrative support.

  • Correspondence should be addressed to either of the following: Dena Dubal, 675 Nelson Rising Line, San Francisco, CA 94158, dena.dubal{at}ucsf.edu; or Lennart Mucke, 1650 Owens Street, San Francisco, CA 94158. lmucke{at}gladstone.ucsf.edu

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2022-08-17
to
E.g., 2022-08-17

Article usage: January 2018 to August 2022

AbstractFullPdf
Jan 20185313537
Feb 20184712333
Mar 20181714916
Apr 20181016129
May 2018209576
Jun 201877575
Jul 201844114
Aug 20183429
Sep 201848115
Oct 20181111517
Nov 2018169924
Dec 20182312121
Total 20182151237366
Jan 20191541822
Feb 201924548
Mar 2019557619
Apr 20191733276283
May 20191477952
Jun 2019406928
Jul 2019416939
Aug 20199414996
Oct 20195421434
Nov 2019518132
Dec 2019316914
Total 201922851554627
Jan 2020328131
Feb 2020316927
Mar 2020266518
May 2020309428
Jun 2020236331
Jul 2020254712
Aug 2020146119
Sep 2020205521
Oct 2020565627
Nov 2020356135
Dec 2020223820
Total 2020314690269
Jan 2021253626
Feb 2021394528
Mar 2021305124
Apr 2021464927
May 2021263814
Jun 2021344821
Jul 2021275736
Aug 2021226617
Sep 2021134218
Oct 2021398647
Nov 2021263825
Dec 2021493424
Total 2021376590307
Jan 2022235013
Feb 2022173720
Mar 2022193621
Apr 2022586220
May 2022194222
Jun 2022195840
Jul 2022352711
Aug 20224277
Total 2022194339154
Total338444101723
Back to top

In this issue

The Journal of Neuroscience: 35 (6)
Journal of Neuroscience
Vol. 35, Issue 6
11 Feb 2015
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Advertising (PDF)
  • Ed Board (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice
Dena B. Dubal, Lei Zhu, Pascal E. Sanchez, Kurtresha Worden, Lauren Broestl, Erik Johnson, Kaitlyn Ho, Gui-Qiu Yu, Daniel Kim, Alexander Betourne, Makoto Kuro-o, Eliezer Masliah, Carmela R. Abraham, Lennart Mucke
Journal of Neuroscience 11 February 2015, 35 (6) 2358-2371; DOI: 10.1523/JNEUROSCI.5791-12.2015

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice
Dena B. Dubal, Lei Zhu, Pascal E. Sanchez, Kurtresha Worden, Lauren Broestl, Erik Johnson, Kaitlyn Ho, Gui-Qiu Yu, Daniel Kim, Alexander Betourne, Makoto Kuro-o, Eliezer Masliah, Carmela R. Abraham, Lennart Mucke
Journal of Neuroscience 11 February 2015, 35 (6) 2358-2371; DOI: 10.1523/JNEUROSCI.5791-12.2015
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • aging
  • Alzheimer's disease
  • cognition
  • klotho
  • mice
  • NMDA receptors

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

Articles

  • Choice Behavior Guided by Learned, But Not Innate, Taste Aversion Recruits the Orbitofrontal Cortex
  • Maturation of Spontaneous Firing Properties after Hearing Onset in Rat Auditory Nerve Fibers: Spontaneous Rates, Refractoriness, and Interfiber Correlations
  • Insulin Treatment Prevents Neuroinflammation and Neuronal Injury with Restored Neurobehavioral Function in Models of HIV/AIDS Neurodegeneration
Show more Articles

Neurobiology of Disease

  • Choice Behavior Guided by Learned, But Not Innate, Taste Aversion Recruits the Orbitofrontal Cortex
  • Maturation of Spontaneous Firing Properties after Hearing Onset in Rat Auditory Nerve Fibers: Spontaneous Rates, Refractoriness, and Interfiber Correlations
  • Insulin Treatment Prevents Neuroinflammation and Neuronal Injury with Restored Neurobehavioral Function in Models of HIV/AIDS Neurodegeneration
Show more Neurobiology of Disease
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
(JNeurosci logo)
(SfN logo)

Copyright © 2022 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.