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Articles, Neurobiology of Disease

Alcohol Decreases Baseline Brain Glucose Metabolism More in Heavy Drinkers Than Controls But Has No Effect on Stimulation-Induced Metabolic Increases

Nora D. Volkow, Gene-Jack Wang, Ehsan Shokri Kojori, Joanna S. Fowler, Helene Benveniste and Dardo Tomasi
Journal of Neuroscience 18 February 2015, 35 (7) 3248-3255; https://doi.org/10.1523/JNEUROSCI.4877-14.2015
Nora D. Volkow
1National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892,
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Gene-Jack Wang
1National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892,
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Ehsan Shokri Kojori
1National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892,
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Joanna S. Fowler
2Biosciences Department, Brookhaven National Laboratory, Upton, New York 11973-5000, and
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Helene Benveniste
3Department of Anesthesiology, Stony Brook Medicine, Stony Brook, New York 11794
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  • ORCID record for Helene Benveniste
Dardo Tomasi
1National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4877-14.2015
PubMed 
25698759
Published By 
Society for Neuroscience
History 
  • Received November 30, 2014
  • Revision received December 29, 2014
  • Accepted January 13, 2015
  • First published February 18, 2015.
  • Version of record published February 18, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/353248-08$15.00/0

Author Information

  1. Nora D. Volkow1,
  2. Gene-Jack Wang1,
  3. Ehsan Shokri Kojori1,
  4. Joanna S. Fowler2,
  5. Helene Benveniste3, and
  6. Dardo Tomasi1
  1. 1National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892,
  2. 2Biosciences Department, Brookhaven National Laboratory, Upton, New York 11973-5000, and
  3. 3Department of Anesthesiology, Stony Brook Medicine, Stony Brook, New York 11794
View Full Text

Author contributions

  1. Author contributions: N.D.V., G.-J.W., J.S.F., and H.B. designed research; G.-J.W., J.S.F., H.B., and D.T. performed research; N.D.V., J.S.F., H.B., and D.T. analyzed data; N.D.V. wrote the paper.

Disclosures

    • Received November 30, 2014.
    • Revision received December 29, 2014.
    • Accepted January 13, 2015.
  • This work was supported by the National Institutes of Health Intramural Research Program. We thank Christopher Wong, Dave Alexoff, Colleen Shea, Pauline Carter, Karen Torres Apelskog, and Ruben Baler for their contributions.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Nora D. Volkow, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, Room 5274, Bethesda, MD 20892. nvolkow{at}nida.nih.gov

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The Journal of Neuroscience: 35 (7)
Journal of Neuroscience
Vol. 35, Issue 7
18 Feb 2015
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Alcohol Decreases Baseline Brain Glucose Metabolism More in Heavy Drinkers Than Controls But Has No Effect on Stimulation-Induced Metabolic Increases
Nora D. Volkow, Gene-Jack Wang, Ehsan Shokri Kojori, Joanna S. Fowler, Helene Benveniste, Dardo Tomasi
Journal of Neuroscience 18 February 2015, 35 (7) 3248-3255; DOI: 10.1523/JNEUROSCI.4877-14.2015

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Alcohol Decreases Baseline Brain Glucose Metabolism More in Heavy Drinkers Than Controls But Has No Effect on Stimulation-Induced Metabolic Increases
Nora D. Volkow, Gene-Jack Wang, Ehsan Shokri Kojori, Joanna S. Fowler, Helene Benveniste, Dardo Tomasi
Journal of Neuroscience 18 February 2015, 35 (7) 3248-3255; DOI: 10.1523/JNEUROSCI.4877-14.2015
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Keywords

  • acetate metabolism
  • alcoholism
  • glial metabolism
  • glycolysis
  • positron emission tomography

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