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Articles, Development/Plasticity/Repair

Anti-Muscarinic Adjunct Therapy Accelerates Functional Human Oligodendrocyte Repair

Kavitha Abiraman, Suyog U. Pol, Melanie A. O'Bara, Guang-Di Chen, Zainab M. Khaku, Jing Wang, David Thorn, Bansi H. Vedia, Ezinne C. Ekwegbalu, Jun-Xu Li, Richard J. Salvi and Fraser J. Sim
Journal of Neuroscience 25 February 2015, 35 (8) 3676-3688; DOI: https://doi.org/10.1523/JNEUROSCI.3510-14.2015
Kavitha Abiraman
1Neuroscience Program,
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Suyog U. Pol
2Department of Pharmacology and Toxicology, and
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Melanie A. O'Bara
2Department of Pharmacology and Toxicology, and
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Guang-Di Chen
3School of Medicine and Biomedical Sciences, Center for Hearing and Deafness, University at Buffalo, Buffalo, New York 14214
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Zainab M. Khaku
2Department of Pharmacology and Toxicology, and
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Jing Wang
2Department of Pharmacology and Toxicology, and
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David Thorn
2Department of Pharmacology and Toxicology, and
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Bansi H. Vedia
2Department of Pharmacology and Toxicology, and
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Ezinne C. Ekwegbalu
2Department of Pharmacology and Toxicology, and
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Jun-Xu Li
2Department of Pharmacology and Toxicology, and
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Richard J. Salvi
3School of Medicine and Biomedical Sciences, Center for Hearing and Deafness, University at Buffalo, Buffalo, New York 14214
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Fraser J. Sim
1Neuroscience Program,
2Department of Pharmacology and Toxicology, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3510-14.2015
PubMed 
25716865
Published By 
Society for Neuroscience
History 
  • Received August 21, 2014
  • Revision received December 24, 2014
  • Accepted January 21, 2015
  • First published February 25, 2015.
  • Version of record published February 25, 2015.
Copyright & Usage 
Copyright © 2015 the authors 0270-6474/15/353676-13$15.00/0

Author Information

  1. Kavitha Abiraman1,*,
  2. Suyog U. Pol2,*,
  3. Melanie A. O'Bara2,
  4. Guang-Di Chen3,
  5. Zainab M. Khaku2,
  6. Jing Wang2,
  7. David Thorn2,
  8. Bansi H. Vedia2,
  9. Ezinne C. Ekwegbalu2,
  10. Jun-Xu Li2,
  11. Richard J. Salvi3, and
  12. Fraser J. Sim1,2
  1. 1Neuroscience Program,
  2. 2Department of Pharmacology and Toxicology, and
  3. 3School of Medicine and Biomedical Sciences, Center for Hearing and Deafness, University at Buffalo, Buffalo, New York 14214
View Full Text

Author contributions

  1. Author contributions: K.A., S.U.P., J.-X.L., R.J.S., and F.J.S. designed research; K.A., S.U.P., M.A.O., G.-D.C., Z.M.K., J.W., D.T., B.H.V., E.C.E., and F.J.S. performed research; K.A., S.U.P., and F.J.S. analyzed data; F.J.S. wrote the paper.

  2. ↵*K.A. and S.U.P. contributed equally to this work.

Disclosures

    • Received August 21, 2014.
    • Revision received December 24, 2014.
    • Accepted January 21, 2015.
  • This work was supported by the National Multiple Sclerosis Society (Grant RG 5505-A-2), the Kalec Multiple Sclerosis Foundation, and the Empire State Stem Cell Fund (New York State Department of Health Contracts C026413 and C028108). The microarray profiling was supported by grants from the National Institutes of Health/National Cancer Institute (Roswell Park Cancer Institute Cancer Center Support Grant P30 CA016056). The auditory evoked potential testing was supported in part by National Institutes of Health Grant R01DC011808. Opinions expressed here are solely those of the authors and do not necessarily reflect those of the Empire State Stem Cell Board, the New York State Department of Health, or the State of New York. We acknowledge the assistance of the Confocal Microscope and Flow Cytometry Facility in the School of Medicine and Biomedical Sciences, University at Buffalo. We thank J. Conroy of the Roswell Park Cancer Institute for assistance with Illumina Beadarray techniques, Katherine Morrison of the Buffalo Women Services clinic, Brad Poulos of the Human Fetal Tissue Repository at the Albert Einstein College of Medicine for assistance with tissue acquisition, and Greg Conway and David Dietz for technical assistance and advice.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Fraser Sim, PhD, Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, University at Buffalo, 3435 Main Street, Buffalo, NY 14214. fjsim{at}buffalo.edu

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Article usage: March 2015 to May 2022

AbstractFullPdf
Feb 201512462771
Mar 20151802166210
Apr 20152403131
May 20151802724
Jun 20151543623
Jul 20151063322
Aug 20151463324
Sep 20151174429
Oct 20152112623
Nov 20151102924
Dec 2015714034
Total 20154383492515
Jan 20161163443
Feb 20161443935
Mar 2016703645
Apr 2016474537
May 2016636337
Jun 2016573332
Jul 2016552129
Aug 2016574127
Sep 2016978332
Oct 20162311820
Nov 2016163026
Dec 2016143822
Total 2016759581385
Jan 2017386522
Feb 20177110710
Mar 201710212011
Apr 2017406319
May 2017224612
Jun 2017214014
Jul 2017203711
Aug 20178316
Sep 201735536
Oct 2017821104
Nov 2017498812
Dec 2017527810
Total 2017540838137
Jan 201842955
Feb 2018444914
Mar 201815385
Apr 201816416
May 201822447
Jun 201813457
Jul 201818406
Aug 2018174013
Sep 2018293811
Oct 2018217513
Nov 20185353
Dec 2018121056
Total 201825464596
Jan 2019219511
Feb 201916122
Mar 2019394120
Apr 2019753214
May 2019393216
Jun 201993112
Jul 2019112412
Aug 2019145711
Sep 201911508
Oct 201931569
Nov 201943209
Dec 2019172011
Total 2019307570135
Jan 20204329
Feb 2020103510
Mar 20204555
Apr 202063813
May 2020163421
Jun 202053214
Jul 202052713
Aug 202042014
Sep 202073214
Oct 202074021
Nov 202092210
Dec 202010195
Total 202087386149
Jan 20218369
Feb 202111164
Mar 202163123
Apr 2021102717
May 2021152316
Jun 20216256
Jul 202161919
Aug 20214197
Sep 202182821
Oct 202172225
Nov 2021151738
Dec 202192943
Total 2021105292228
Jan 2022121824
Feb 20227237
Mar 20228266
Apr 202263414
May 202292722
Total 20224212873
Total647739321718
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The Journal of Neuroscience: 35 (8)
Journal of Neuroscience
Vol. 35, Issue 8
25 Feb 2015
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Anti-Muscarinic Adjunct Therapy Accelerates Functional Human Oligodendrocyte Repair
Kavitha Abiraman, Suyog U. Pol, Melanie A. O'Bara, Guang-Di Chen, Zainab M. Khaku, Jing Wang, David Thorn, Bansi H. Vedia, Ezinne C. Ekwegbalu, Jun-Xu Li, Richard J. Salvi, Fraser J. Sim
Journal of Neuroscience 25 February 2015, 35 (8) 3676-3688; DOI: 10.1523/JNEUROSCI.3510-14.2015

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Anti-Muscarinic Adjunct Therapy Accelerates Functional Human Oligodendrocyte Repair
Kavitha Abiraman, Suyog U. Pol, Melanie A. O'Bara, Guang-Di Chen, Zainab M. Khaku, Jing Wang, David Thorn, Bansi H. Vedia, Ezinne C. Ekwegbalu, Jun-Xu Li, Richard J. Salvi, Fraser J. Sim
Journal of Neuroscience 25 February 2015, 35 (8) 3676-3688; DOI: 10.1523/JNEUROSCI.3510-14.2015
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Keywords

  • glia
  • human
  • microarray
  • oligodendrocyte

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