Articles, Cellular/Molecular

Obesity Is Associated with Decreased μ-Opioid But Unaltered Dopamine D2 Receptor Availability in the Brain

Henry K. Karlsson, Lauri Tuominen, Jetro J. Tuulari, Jussi Hirvonen, Riitta Parkkola, Semi Helin, Paulina Salminen, Pirjo Nuutila and Lauri Nummenmaa
Journal of Neuroscience 4 March 2015, 35 (9) 3959-3965; DOI: https://doi.org/10.1523/JNEUROSCI.4744-14.2015

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  • Submitted on: (5 March 2015)
    Page navigation anchor for Important indication of opioid involvement in obesity
    Important indication of opioid involvement in obesity

    I am pleased to see this confirmation and extension of our discovery 37 years ago in genetically obese mice and rats.

    Margules, D. L., Moisset, B., Lewis, M. J., Shibuya, H., & Pert, C. B. (1978). Beta-endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa). Science, 202, 988-991.

    It extends our discovery to humans, shows how much of the brain is involved, rules...

    Show More
    Competing Interests: None declared.
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Obesity Is Associated with Decreased μ-Opioid But Unaltered Dopamine D2 Receptor Availability in the Brain
Henry K. Karlsson, Lauri Tuominen, Jetro J. Tuulari, Jussi Hirvonen, Riitta Parkkola, Semi Helin, Paulina Salminen, Pirjo Nuutila, Lauri Nummenmaa
Journal of Neuroscience 4 March 2015, 35 (9) 3959-3965; DOI: 10.1523/JNEUROSCI.4744-14.2015
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Jump to comment:

  • Published on: (5 March 2015)
    Page navigation anchor for Important indication of opioid involvement in obesity
    Important indication of opioid involvement in obesity

    I am pleased to see this confirmation and extension of our discovery 37 years ago in genetically obese mice and rats.

    Margules, D. L., Moisset, B., Lewis, M. J., Shibuya, H., & Pert, C. B. (1978). Beta-endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa). Science, 202, 988-991.

    It extends our discovery to humans, shows how much of the brain is involved, rules...

    Show More
    Competing Interests: None declared.