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Articles, Systems/Circuits

Top-Down-Mediated Facilitation in the Visual Cortex Is Gated by Subcortical Neuromodulation

Diego E. Pafundo, Mark A. Nicholas, Ruilin Zhang and Sandra J. Kuhlman
Journal of Neuroscience 9 March 2016, 36 (10) 2904-2914; https://doi.org/10.1523/JNEUROSCI.2909-15.2016
Diego E. Pafundo
Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
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Mark A. Nicholas
Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
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Ruilin Zhang
Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
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Sandra J. Kuhlman
Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2909-15.2016
PubMed 
26961946
Published By 
Society for Neuroscience
History 
  • Received August 1, 2015
  • Revision received January 18, 2016
  • Accepted January 19, 2016
  • First published March 9, 2016.
  • Version of record published March 9, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/362904-11$15.00/0

Author Information

  1. Diego E. Pafundo,
  2. Mark A. Nicholas,
  3. Ruilin Zhang, and
  4. Sandra J. Kuhlman
  1. Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
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Author contributions

  1. Author contributions: D.E.P., M.A.N., and S.J.K. designed research; D.E.P., M.A.N., and R.Z. performed research; D.E.P., R.Z., and S.J.K. analyzed data; D.E.P. and S.J.K. wrote the paper.

Disclosures

    • Received August 1, 2015.
    • Revision received January 18, 2016.
    • Accepted January 19, 2016.
  • This work was supported by the Knights Templar Eye Foundation (D.E.P.), the Howard Hughes Medical Institute Undergraduate Program (M.A.N.), the Fight-For-Sight Foundation (S.J.K.), and the National Institutes of Health (Grant R01EY024678 to S.J.K.).We thank Tony Grace, Tomek Banasikowski, Aryn Gittis, and Rachel Bouchard for help with BF experiments; Spencer Smith, Ikuko Smith, and Ian Nauhaus for assistance in acquiring and analyzing intrinsic signal optical imaging data; and Aryn Gittis and Alison Barth for comments on an earlier version of the manuscript.

  • Correspondence should be addressed to Sandra J. Kuhlman, Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, 4400 5th Ave., Pittsburgh, PA 15213. skuhlman{at}cmu.edu

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Total123640811311
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The Journal of Neuroscience: 36 (10)
Journal of Neuroscience
Vol. 36, Issue 10
9 Mar 2016
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Top-Down-Mediated Facilitation in the Visual Cortex Is Gated by Subcortical Neuromodulation
Diego E. Pafundo, Mark A. Nicholas, Ruilin Zhang, Sandra J. Kuhlman
Journal of Neuroscience 9 March 2016, 36 (10) 2904-2914; DOI: 10.1523/JNEUROSCI.2909-15.2016

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Top-Down-Mediated Facilitation in the Visual Cortex Is Gated by Subcortical Neuromodulation
Diego E. Pafundo, Mark A. Nicholas, Ruilin Zhang, Sandra J. Kuhlman
Journal of Neuroscience 9 March 2016, 36 (10) 2904-2914; DOI: 10.1523/JNEUROSCI.2909-15.2016
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Keywords

  • basal forebrain
  • GABAergic
  • nucleus basalis
  • optogenetic
  • parvalbumin
  • primary visual cortex

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