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Articles, Cellular/Molecular

A Network of Three Types of Filaments Organizes Synaptic Vesicles for Storage, Mobilization, and Docking

Andy A. Cole, Xiaobing Chen and Thomas S. Reese
Journal of Neuroscience 16 March 2016, 36 (11) 3222-3230; DOI: https://doi.org/10.1523/JNEUROSCI.2939-15.2016
Andy A. Cole
1Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, and
2Department of Cellular and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611
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Xiaobing Chen
1Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, and
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Thomas S. Reese
1Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2939-15.2016
PubMed 
26985032
Published By 
Society for Neuroscience
History 
  • Received August 4, 2015
  • Revision received January 29, 2016
  • Accepted February 5, 2016
  • First published March 16, 2016.
  • Version of record published March 16, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/363222-09$15.00/0

Author Information

  1. Andy A. Cole1,2,
  2. Xiaobing Chen1, and
  3. Thomas S. Reese1
  1. 1Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, and
  2. 2Department of Cellular and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611
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Author contributions

  1. Author contributions: A.A.C. designed research; A.A.C. and X.C. performed research; A.A.C., X.C., and T.S.R. analyzed data; A.A.C. and T.S.R. wrote the paper.

Disclosures

    • Received August 4, 2015.
    • Revision received January 29, 2016.
    • Accepted February 5, 2016.
  • This research was supported by the Intramural Research Program of the National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke. We thank Dr. Richard Leapman, National Institute of Biomedical Imaging and Bioengineering, NIH, for the use of his FEI Tecnai 300 kV electron microscope and his support in the acquisition of tomographic data; Rita Azzam and Virginia Crocker for preparing the sections for tomography; and Christine Winters for preparing hippocampal cultures, as well as performing high-pressure freezing and freeze-substitution for tomography.

  • Correspondence should be addressed to Andy A. Cole, Laboratory of Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 49 Convent Drive, Room 3A68, Bethesda, MD 20892. cole.andy.a{at}gmail.com

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Jan 201813511
Feb 2018112510
Mar 201815269
Apr 20189344
May 201812274
Jun 20184298
Jul 20186299
Aug 20181209
Sep 20180257
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Nov 20187286
Dec 20185178
Total 20187532092
Jan 20193194
Feb 20193183
Mar 20196179
Apr 2019101915
May 201962013
Jun 201952011
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Aug 20194128
Oct 201942110
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Feb 20203179
Mar 202032112
May 2020111513
Jun 20206179
Jul 202042710
Aug 2020297
Sep 20204237
Oct 2020118220
Nov 202033412
Dec 2020113712
Total 202065290119
Jan 202193216
Feb 202151810
Mar 202181923
Apr 202121514
May 202142914
Jun 20214204
Jul 202141010
Aug 20219139
Sep 202141711
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Total 202166250162
Jan 20229237
Feb 20223146
Mar 20229259
Apr 20224248
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Jun 202232032
Jul 20226126
Aug 202251811
Sep 2022289
Oct 202242210
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Total 202252187133
Jan 20233304
Total 20233304
Total3151277624
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The Journal of Neuroscience: 36 (11)
Journal of Neuroscience
Vol. 36, Issue 11
16 Mar 2016
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A Network of Three Types of Filaments Organizes Synaptic Vesicles for Storage, Mobilization, and Docking
Andy A. Cole, Xiaobing Chen, Thomas S. Reese
Journal of Neuroscience 16 March 2016, 36 (11) 3222-3230; DOI: 10.1523/JNEUROSCI.2939-15.2016

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A Network of Three Types of Filaments Organizes Synaptic Vesicles for Storage, Mobilization, and Docking
Andy A. Cole, Xiaobing Chen, Thomas S. Reese
Journal of Neuroscience 16 March 2016, 36 (11) 3222-3230; DOI: 10.1523/JNEUROSCI.2939-15.2016
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Keywords

  • docking
  • presynaptic
  • storage
  • synaptic vesicles
  • tomography
  • vesicle mobilization

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