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Cover ArticleFeatured ArticleArticles, Systems/Circuits

Opening Holes in the Blanket of Inhibition: Localized Lateral Disinhibition by VIP Interneurons

Mahesh M. Karnani, Jesse Jackson, Inbal Ayzenshtat, Azadeh Hamzehei Sichani, Kasra Manoocheri, Samuel Kim and Rafael Yuste
Journal of Neuroscience 23 March 2016, 36 (12) 3471-3480; https://doi.org/10.1523/JNEUROSCI.3646-15.2016
Mahesh M. Karnani
Neurotechnology Center, Department of Biological Sciences, Columbia University, New York, New York 10027
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Jesse Jackson
Neurotechnology Center, Department of Biological Sciences, Columbia University, New York, New York 10027
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Inbal Ayzenshtat
Neurotechnology Center, Department of Biological Sciences, Columbia University, New York, New York 10027
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Azadeh Hamzehei Sichani
Neurotechnology Center, Department of Biological Sciences, Columbia University, New York, New York 10027
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Kasra Manoocheri
Neurotechnology Center, Department of Biological Sciences, Columbia University, New York, New York 10027
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Samuel Kim
Neurotechnology Center, Department of Biological Sciences, Columbia University, New York, New York 10027
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Rafael Yuste
Neurotechnology Center, Department of Biological Sciences, Columbia University, New York, New York 10027
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3646-15.2016
PubMed 
27013676
Published By 
Society for Neuroscience
History 
  • Received October 2, 2015
  • Revision received December 26, 2015
  • Accepted January 20, 2016
  • First published March 23, 2016.
  • Version of record published March 23, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/363471-10$15.00/0

Author Information

  1. Mahesh M. Karnani,
  2. Jesse Jackson,
  3. Inbal Ayzenshtat,
  4. Azadeh Hamzehei Sichani,
  5. Kasra Manoocheri,
  6. Samuel Kim, and
  7. Rafael Yuste
  1. Neurotechnology Center, Department of Biological Sciences, Columbia University, New York, New York 10027
View Full Text

Author contributions

  1. Author contributions: M.M.K., J.J., and R.Y. designed research; M.M.K., J.J., I.A., A.H.S., K.M., and S.K. performed research; M.M.K., J.J., and I.A. analyzed data; M.M.K. wrote the paper.

Disclosures

    • Received October 2, 2015.
    • Revision received December 26, 2015.
    • Accepted January 20, 2016.
  • This work was funded by NIH R01EY011787 and DP1EY024503, NIMH (R01MH101218, R01MH100561), DARPA SIMPLEX n66001-15-C-4032M, and ARO W911NF-12-1-0594(MURI) to R.Y., HFSP long-term fellowship to M.M.K., Canadian Institute for Health Research fellowship to J.J. and Marie Curie IOF to I.A. We thank Darcy Peterka, Benjamin Shababo, Yeonsook Shin, Alexa Semonche, and Weijian Yang for technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr Mahesh Karnani, Department of Biological Sciences, Columbia University, 901 NWC Building, MC4822, 550 West 120th Street, New York, NY 10027. miikael.mmk{at}gmail.com

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The Journal of Neuroscience: 36 (12)
Journal of Neuroscience
Vol. 36, Issue 12
23 Mar 2016
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Opening Holes in the Blanket of Inhibition: Localized Lateral Disinhibition by VIP Interneurons
Mahesh M. Karnani, Jesse Jackson, Inbal Ayzenshtat, Azadeh Hamzehei Sichani, Kasra Manoocheri, Samuel Kim, Rafael Yuste
Journal of Neuroscience 23 March 2016, 36 (12) 3471-3480; DOI: 10.1523/JNEUROSCI.3646-15.2016

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Opening Holes in the Blanket of Inhibition: Localized Lateral Disinhibition by VIP Interneurons
Mahesh M. Karnani, Jesse Jackson, Inbal Ayzenshtat, Azadeh Hamzehei Sichani, Kasra Manoocheri, Samuel Kim, Rafael Yuste
Journal of Neuroscience 23 March 2016, 36 (12) 3471-3480; DOI: 10.1523/JNEUROSCI.3646-15.2016
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Keywords

  • disinhibition
  • interneuron
  • neocortex
  • vasoactive intestinal peptide
  • VIP

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