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Articles, Development/Plasticity/Repair

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

Somsak Wattananit, Daniel Tornero, Nadine Graubardt, Tamar Memanishvili, Emanuela Monni, Jemal Tatarishvili, Giedre Miskinyte, Ruimin Ge, Henrik Ahlenius, Olle Lindvall, Michal Schwartz and Zaal Kokaia
Journal of Neuroscience 13 April 2016, 36 (15) 4182-4195; DOI: https://doi.org/10.1523/JNEUROSCI.4317-15.2016
Somsak Wattananit
1Laboratory of Stem Cells and Restorative Neurology and
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Daniel Tornero
1Laboratory of Stem Cells and Restorative Neurology and
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Nadine Graubardt
3Department of Neurobiology, Weizmann Institute of Science, 7610001, Rehovot, Israel, and
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Tamar Memanishvili
1Laboratory of Stem Cells and Restorative Neurology and
4I. Javakhishvili Tbilisi State University, 0179, Tbilisi, Georgia
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  • ORCID record for Tamar Memanishvili
Emanuela Monni
1Laboratory of Stem Cells and Restorative Neurology and
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Jemal Tatarishvili
1Laboratory of Stem Cells and Restorative Neurology and
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Giedre Miskinyte
1Laboratory of Stem Cells and Restorative Neurology and
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Ruimin Ge
1Laboratory of Stem Cells and Restorative Neurology and
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Henrik Ahlenius
2Stem Cells, Aging, and Neurodegeneration Group, Lund Stem Cell Center, University Hospital, 221 84, Lund, Sweden,
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Olle Lindvall
1Laboratory of Stem Cells and Restorative Neurology and
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Michal Schwartz
3Department of Neurobiology, Weizmann Institute of Science, 7610001, Rehovot, Israel, and
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Zaal Kokaia
1Laboratory of Stem Cells and Restorative Neurology and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4317-15.2016
PubMed 
27076418
Published By 
Society for Neuroscience
History 
  • Received December 1, 2015
  • Revision received February 14, 2016
  • Accepted March 1, 2016
  • First published April 13, 2016.
  • Version of record published April 13, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/364182-14$15.00/0

Author Information

  1. Somsak Wattananit1,
  2. Daniel Tornero1,
  3. Nadine Graubardt3,
  4. Tamar Memanishvili1,4,
  5. Emanuela Monni1,
  6. Jemal Tatarishvili1,
  7. Giedre Miskinyte1,
  8. Ruimin Ge1,
  9. Henrik Ahlenius2,
  10. Olle Lindvall1,
  11. Michal Schwartz3, and
  12. Zaal Kokaia1
  1. 1Laboratory of Stem Cells and Restorative Neurology and
  2. 2Stem Cells, Aging, and Neurodegeneration Group, Lund Stem Cell Center, University Hospital, 221 84, Lund, Sweden,
  3. 3Department of Neurobiology, Weizmann Institute of Science, 7610001, Rehovot, Israel, and
  4. 4I. Javakhishvili Tbilisi State University, 0179, Tbilisi, Georgia
  • S. Wattananit's present address: Department of Clinical Sciences and Public Health Medicine, Faculty of Veterinary Science, Mahidol University, Nakorn Prathom 73170, Thailand.

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Author contributions

  1. Author contributions: S.W., O.L., M.S., and Z.K. designed research; S.W., D.T., N.G., T.M., E.M., J.T., G.M., R.G., H.A., and Z.K. performed research; S.W., D.T., T.M., E.M., and Z.K. analyzed data; S.W., O.L., M.S., and Z.K. wrote the paper.

  • S. Wattananit's present address: Department of Clinical Sciences and Public Health Medicine, Faculty of Veterinary Science, Mahidol University, Nakorn Prathom 73170, Thailand.

View Abstract

Disclosures

    • Received December 1, 2015.
    • Revision received February 14, 2016.
    • Accepted March 1, 2016.
  • This work was supported by European Union Project TargetBraIn Grant 279017, the Swedish Research Council, the AFA Foundation, the Ragnar Söderberg Foundation, and the Swedish Government Initiative for Strategic Research Areas (StemTherapy). S.W. and T.M. were partly supported by the Program of Strategic Scholarships for Frontier Research Network, Thailand's Office of the Higher Education Commission, and Shota Rustaveli National Science Foundation (Tbilisi, Georgia), respectively. We thank Dr. Talia Velasco for help with monocyte isolation, Zhi Ma and Teona Roschupkina for help with cell sorting, and Linda Jansson for technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Zaal Kokaia, Laboratory of Stem Cells and Restorative Neurology, Lund Stem Cell Center, University Hospital, SE-221 84 Lund, Sweden. zaal.kokaia{at}med.lu.se

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Article usage: April 2016 to January 2021

AbstractFullPdf
Apr 20164412217407
May 2016808121124
Jun 20163507162
Jul 20162066353
Aug 20163336556
Sep 20162479492
Oct 201614113872
Nov 201676177139
Dec 201633122278
Total 2016660610681283
Jan 201791169138
Feb 201711515891
Mar 2017177169109
Apr 20176213770
May 20174410268
Jun 2017439661
Jul 2017306058
Aug 2017398251
Sep 20174612561
Oct 20178111570
Nov 20171139660
Dec 20176310859
Total 20179041417896
Jan 20186513789
Feb 20184411978
Mar 20181418177
Apr 20181315171
May 20182113777
Jun 20181112561
Jul 20182013468
Aug 20181711188
Sep 2018209274
Oct 20182713091
Nov 20182210579
Dec 20181410360
Total 20182881525913
Jan 201917129114
Feb 201918129110
Mar 20192110585
Apr 201954127107
May 201932160153
Jun 201912142125
Jul 20199103105
Aug 2019159497
Sep 201997383
Oct 201927100120
Nov 201926123106
Dec 2019109381
Total 201925013781286
Jan 2020106997
Feb 2020108590
Mar 20201189108
Apr 20201789110
May 20201610494
Jun 20201193161
Jul 202056584
Aug 202085053
Sep 20201777115
Oct 20201212194
Nov 2020235074
Dec 2020187193
Total 20201589631173
Jan 2021154851
Total 2021154851
Total822163995602
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The Journal of Neuroscience: 36 (15)
Journal of Neuroscience
Vol. 36, Issue 15
13 Apr 2016
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Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice
Somsak Wattananit, Daniel Tornero, Nadine Graubardt, Tamar Memanishvili, Emanuela Monni, Jemal Tatarishvili, Giedre Miskinyte, Ruimin Ge, Henrik Ahlenius, Olle Lindvall, Michal Schwartz, Zaal Kokaia
Journal of Neuroscience 13 April 2016, 36 (15) 4182-4195; DOI: 10.1523/JNEUROSCI.4317-15.2016

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Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice
Somsak Wattananit, Daniel Tornero, Nadine Graubardt, Tamar Memanishvili, Emanuela Monni, Jemal Tatarishvili, Giedre Miskinyte, Ruimin Ge, Henrik Ahlenius, Olle Lindvall, Michal Schwartz, Zaal Kokaia
Journal of Neuroscience 13 April 2016, 36 (15) 4182-4195; DOI: 10.1523/JNEUROSCI.4317-15.2016
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Keywords

  • macrophage
  • microglia
  • monocyte
  • neuroinflammation
  • stroke

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