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Articles, Cellular/Molecular

Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection

Narumi Sato-Akuhara, Nao Horio, Aya Kato-Namba, Keiichi Yoshikawa, Yoshihito Niimura, Sayoko Ihara, Mika Shirasu and Kazushige Touhara
Journal of Neuroscience 20 April 2016, 36 (16) 4482-4491; https://doi.org/10.1523/JNEUROSCI.3259-15.2016
Narumi Sato-Akuhara
1Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan,
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Nao Horio
1Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan,
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Aya Kato-Namba
3Kansei Science Research, Kao Corporation, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan
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Keiichi Yoshikawa
3Kansei Science Research, Kao Corporation, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan
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Yoshihito Niimura
1Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan,
2ERATO Touhara Chemosensory Signal Project, the Japan Science and Technology Agency, The University of Tokyo, Tokyo 113-8657, Japan, and
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Sayoko Ihara
1Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan,
2ERATO Touhara Chemosensory Signal Project, the Japan Science and Technology Agency, The University of Tokyo, Tokyo 113-8657, Japan, and
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Mika Shirasu
1Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan,
2ERATO Touhara Chemosensory Signal Project, the Japan Science and Technology Agency, The University of Tokyo, Tokyo 113-8657, Japan, and
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Kazushige Touhara
1Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan,
2ERATO Touhara Chemosensory Signal Project, the Japan Science and Technology Agency, The University of Tokyo, Tokyo 113-8657, Japan, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3259-15.2016
PubMed 
27098692
Published By 
Society for Neuroscience
History 
  • Received August 31, 2015
  • Revision received February 24, 2016
  • Accepted March 1, 2016
  • First published April 20, 2016.
  • Version of record published April 20, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/364482-10$15.00/0

Author Information

  1. Narumi Sato-Akuhara1,
  2. Nao Horio1,
  3. Aya Kato-Namba3,
  4. Keiichi Yoshikawa3,
  5. Yoshihito Niimura1,2,
  6. Sayoko Ihara1,2,
  7. Mika Shirasu1,2, and
  8. Kazushige Touhara1,2
  1. 1Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan,
  2. 2ERATO Touhara Chemosensory Signal Project, the Japan Science and Technology Agency, The University of Tokyo, Tokyo 113-8657, Japan, and
  3. 3Kansei Science Research, Kao Corporation, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan
View Full Text

Author contributions

  1. Author contributions: N.S.-A., M.S., and K.T. designed research; N.S.-A., N.H., A.K.-N., K.Y., and Y.N. performed research; N.S.-A., N.H., A.K.-N., K.Y., Y.N., S.I., M.S., and K.T. analyzed data; N.S.-A., M.S., and K.T. wrote the paper.

Disclosures

    • Received August 31, 2015.
    • Revision received February 24, 2016.
    • Accepted March 1, 2016.
  • This work was supported by MEXT Japan (Grant-in-Aid for Scientific Research–S 24227003) and the Japanese Science and Technology Agency ERATO Touhara Chemosensory Signal Project. We thank Takasago International for providing highly pure musk odorants; Nagoya Higashiyama Zoo and Botanical Gardens for providing the orangutan sample (Baran, GAIN ID 0008) through the Great Ape Information Network and Primate Research Institute in Kyoto University; and H. Sakano for providing KO mice.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either Kazushige Touhara or Mika Shirasu, Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan, ktouhara{at}mail.ecc.u-tokyo.ac.jp or ashirasu{at}mail.ecc.u-tokyo.ac.jp

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The Journal of Neuroscience: 36 (16)
Journal of Neuroscience
Vol. 36, Issue 16
20 Apr 2016
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Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection
Narumi Sato-Akuhara, Nao Horio, Aya Kato-Namba, Keiichi Yoshikawa, Yoshihito Niimura, Sayoko Ihara, Mika Shirasu, Kazushige Touhara
Journal of Neuroscience 20 April 2016, 36 (16) 4482-4491; DOI: 10.1523/JNEUROSCI.3259-15.2016

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Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection
Narumi Sato-Akuhara, Nao Horio, Aya Kato-Namba, Keiichi Yoshikawa, Yoshihito Niimura, Sayoko Ihara, Mika Shirasu, Kazushige Touhara
Journal of Neuroscience 20 April 2016, 36 (16) 4482-4491; DOI: 10.1523/JNEUROSCI.3259-15.2016
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Keywords

  • evolution
  • human
  • mouse
  • MuSK
  • olfactory
  • receptor

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