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PreviousNext
Featured ArticleArticles, Cellular/Molecular

Targeted Epigenetic Remodeling of the Cdk5 Gene in Nucleus Accumbens Regulates Cocaine- and Stress-Evoked Behavior

Elizabeth A. Heller, Peter J. Hamilton, Dominika D. Burek, Sonia I. Lombroso, Catherine J. Peña, Rachael L. Neve and Eric J. Nestler
Journal of Neuroscience 27 April 2016, 36 (17) 4690-4697; DOI: https://doi.org/10.1523/JNEUROSCI.0013-16.2016
Elizabeth A. Heller
1Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, and
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Peter J. Hamilton
1Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, and
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Dominika D. Burek
1Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, and
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Sonia I. Lombroso
1Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, and
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  • ORCID record for Sonia I. Lombroso
Catherine J. Peña
1Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, and
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Rachael L. Neve
2McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
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Eric J. Nestler
1Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0013-16.2016
PubMed 
27122028
Published By 
Society for Neuroscience
History 
  • Received January 2, 2016
  • Revision received February 17, 2016
  • Accepted March 9, 2016
  • First published April 27, 2016.
  • Version of record published April 27, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/364690-08$15.00/0

Author Information

  1. Elizabeth A. Heller1,*,
  2. Peter J. Hamilton1,*,
  3. Dominika D. Burek1,
  4. Sonia I. Lombroso1,
  5. Catherine J. Peña1,
  6. Rachael L. Neve2, and
  7. Eric J. Nestler1
  1. 1Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, and
  2. 2McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
  • E.A. Heller's present address: Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia PA 19104.

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Author contributions

  1. Author contributions: E.A.H., P.J.H., and E.J.N. designed research; E.A.H., P.J.H., D.D.B., and S.I.L. performed research; R.L.N. contributed unpublished reagents/analytic tools; E.A.H., P.J.H., D.D.B., C.J.P., and E.J.N. analyzed data; E.A.H., P.J.H., and E.J.N. wrote the paper.

  2. ↵*E.A.H. and P.J.H. contributed equally to this work.

  • E.A. Heller's present address: Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia PA 19104.

Disclosures

    • Received January 2, 2016.
    • Revision received February 17, 2016.
    • Accepted March 9, 2016.
  • This work was supported by National Institute on Drug Abuse Grant R37DA008227 and National Institute of Mental Health Grant P50MH096890 to E.J.N., and by The Robin Chemers Neustein Postdoctoral Fellowship to E.A.H.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Elizabeth A. Heller, Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA 19104. eheller{at}mail.med.upenn.edu

Online Impact

 

Article usage

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Article usage: April 2016 to May 2022

AbstractFullPdf
Apr 2016261774183
May 20162048187190
Jun 20162707443
Jul 20161524946
Aug 20161185025
Sep 20161386153
Oct 20161155730
Nov 2016709044
Dec 2016315940
Total 20165559701654
Jan 2017775537
Feb 20171156629
Mar 20171345426
Apr 2017534125
May 2017244220
Jun 2017203515
Jul 2017162314
Aug 2017223422
Sep 2017422814
Oct 20171033623
Nov 2017635123
Dec 2017613017
Total 2017730495265
Jan 2018392412
Feb 2018522015
Mar 2018303312
Apr 201821289
May 20189285
Jun 201811308
Jul 2018142411
Aug 2018132513
Sep 201815319
Oct 201821189
Nov 2018182717
Dec 201823126
Total 2018266300126
Jan 20193222
Feb 201910198
Mar 2019414021
Apr 2019552113
May 2019102416
Jun 201953518
Jul 201962014
Aug 201963315
Sep 201962912
Oct 201924189
Nov 2019393220
Dec 2019183414
Total 2019223327162
Jan 202062816
Feb 20201111711
Mar 2020153321
Apr 2020132916
May 202091914
Jun 202081919
Jul 202091817
Aug 20208136
Sep 2020122612
Oct 202075726
Nov 2020104225
Dec 202011269
Total 2020119427192
Jan 202193122
Feb 202163117
Mar 2021123124
Apr 202173913
May 202191715
Jun 2021102719
Jul 202121218
Aug 20214225
Sep 202191814
Oct 202142729
Nov 202152523
Dec 202182011
Total 202185300210
Jan 20221228
Feb 202251912
Mar 2022122216
Apr 20226189
May 20222813
Total 2022268958
Total700826391667
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The Journal of Neuroscience: 36 (17)
Journal of Neuroscience
Vol. 36, Issue 17
27 Apr 2016
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Targeted Epigenetic Remodeling of the Cdk5 Gene in Nucleus Accumbens Regulates Cocaine- and Stress-Evoked Behavior
Elizabeth A. Heller, Peter J. Hamilton, Dominika D. Burek, Sonia I. Lombroso, Catherine J. Peña, Rachael L. Neve, Eric J. Nestler
Journal of Neuroscience 27 April 2016, 36 (17) 4690-4697; DOI: 10.1523/JNEUROSCI.0013-16.2016

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Targeted Epigenetic Remodeling of the Cdk5 Gene in Nucleus Accumbens Regulates Cocaine- and Stress-Evoked Behavior
Elizabeth A. Heller, Peter J. Hamilton, Dominika D. Burek, Sonia I. Lombroso, Catherine J. Peña, Rachael L. Neve, Eric J. Nestler
Journal of Neuroscience 27 April 2016, 36 (17) 4690-4697; DOI: 10.1523/JNEUROSCI.0013-16.2016
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Keywords

  • Ckd5
  • epigenetics
  • zinc finger

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