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Articles, Neurobiology of Disease

Oligodendrogliopathy in Multiple Sclerosis: Low Glycolytic Metabolic Rate Promotes Oligodendrocyte Survival

Malena B. Rone, Qiao-Ling Cui, Jun Fang, Li-Chun Wang, Ji Zhang, Damla Khan, Melissa Bedard, Guillermina Almazan, Samuel K. Ludwin, Russel Jones, Timothy E. Kennedy and Jack P. Antel
Journal of Neuroscience 27 April 2016, 36 (17) 4698-4707; DOI: https://doi.org/10.1523/JNEUROSCI.4077-15.2016
Malena B. Rone
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada,
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Qiao-Ling Cui
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada,
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Jun Fang
2Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada, and
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Li-Chun Wang
2Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada, and
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  • ORCID record for Li-Chun Wang
Ji Zhang
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada,
3Alan Edwards Centre for Research on Pain and
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Damla Khan
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada,
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Melissa Bedard
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada,
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Guillermina Almazan
2Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada, and
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Samuel K. Ludwin
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada,
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Russel Jones
4Department of Physiology, McGill University, Montreal, Quebec H3A 0G4, Canada
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Timothy E. Kennedy
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada,
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Jack P. Antel
1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4077-15.2016
PubMed 
27122029
Published By 
Society for Neuroscience
History 
  • Received November 11, 2015
  • Revision received January 28, 2016
  • Accepted February 21, 2016
  • First published April 27, 2016.
  • Version of record published April 27, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/364698-10$15.00/0

Author Information

  1. Malena B. Rone1,*,
  2. Qiao-Ling Cui1,*,
  3. Jun Fang2,
  4. Li-Chun Wang2,
  5. Ji Zhang1,3,
  6. Damla Khan1,
  7. Melissa Bedard1,
  8. Guillermina Almazan2,
  9. Samuel K. Ludwin1,
  10. Russel Jones4,
  11. Timothy E. Kennedy1, and
  12. Jack P. Antel1
  1. 1Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada,
  2. 2Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada, and
  3. 3Alan Edwards Centre for Research on Pain and
  4. 4Department of Physiology, McGill University, Montreal, Quebec H3A 0G4, Canada
View Full Text

Author contributions

  1. Author contributions: M.B.R. and Q.-L.C. designed research; M.B.R., Q.-L.C., J.F., L.-C.W., and M.B. performed research; M.B.R., Q.-L.C., and J.Z. contributed unpublished reagents/analytic tools; M.B.R., Q.-L.C., D.K., G.A., S.K.L., R.J., T.E.K., and J.P.A. analyzed data; M.B.R., Q.-L.C., J.Z., G.A., S.K.L., R.J., T.E.K., and J.P.A. wrote the paper.

  2. ↵*M.B.R. and Q.-L.C. contributed equally to this study.

Disclosures

    • Received November 11, 2015.
    • Revision received January 28, 2016.
    • Accepted February 21, 2016.
  • This work was supported by an operating grant from the MS Society of Canada. M.B.R. was supported by a postdoctoral fellowship from the MS Society of Canada.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Jack P. Antel, Neuroimmunology Unit, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada. jack.antel{at}mcgill.ca

Online Impact

 

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Article usage: April 2016 to May 2022

AbstractFullPdf
Apr 2016160351130
May 20161115161145
Jun 20161853636
Jul 20161273133
Aug 2016843225
Sep 2016903118
Oct 2016873322
Nov 2016397360
Dec 2016304935
Total 20163360497504
Jan 2017566331
Feb 2017947728
Mar 20171179932
Apr 2017405477
May 2017296128
Jun 2017277026
Jul 2017146714
Aug 2017184917
Sep 2017275827
Oct 2017465223
Nov 2017755315
Dec 2017495017
Total 2017592753335
Jan 2018494223
Feb 2018326028
Mar 2018136021
Apr 2018928523
May 20181510816
Jun 20186739
Jul 201848316
Aug 20182646
Sep 2018146415
Oct 20181110321
Nov 201888213
Dec 201820448
Total 20181831068199
Jan 201945321
Feb 2019127014
Mar 2019285525
Apr 2019435420
May 2019146328
Jun 201945717
Jul 201955115
Aug 201906215
Sep 201945918
Oct 20191810319
Nov 2019316227
Dec 2019144613
Total 2019177735232
Jan 202033813
Feb 202064316
Mar 202084728
Apr 202074435
May 202072921
Jun 202032515
Jul 202024218
Aug 202064015
Sep 202084224
Oct 202084124
Nov 202083013
Dec 202092222
Total 202075443244
Jan 202181812
Feb 202110307
Mar 2021103517
Apr 202162912
May 202153319
Jun 202132610
Jul 202133110
Aug 202173417
Sep 202184914
Oct 202154224
Nov 2021104433
Dec 202164413
Total 202181415188
Jan 202284015
Feb 20225436
Mar 2022154011
Apr 202257612
May 20221567
Total 20223425551
Total450241661753
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The Journal of Neuroscience: 36 (17)
Journal of Neuroscience
Vol. 36, Issue 17
27 Apr 2016
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Oligodendrogliopathy in Multiple Sclerosis: Low Glycolytic Metabolic Rate Promotes Oligodendrocyte Survival
Malena B. Rone, Qiao-Ling Cui, Jun Fang, Li-Chun Wang, Ji Zhang, Damla Khan, Melissa Bedard, Guillermina Almazan, Samuel K. Ludwin, Russel Jones, Timothy E. Kennedy, Jack P. Antel
Journal of Neuroscience 27 April 2016, 36 (17) 4698-4707; DOI: 10.1523/JNEUROSCI.4077-15.2016

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Oligodendrogliopathy in Multiple Sclerosis: Low Glycolytic Metabolic Rate Promotes Oligodendrocyte Survival
Malena B. Rone, Qiao-Ling Cui, Jun Fang, Li-Chun Wang, Ji Zhang, Damla Khan, Melissa Bedard, Guillermina Almazan, Samuel K. Ludwin, Russel Jones, Timothy E. Kennedy, Jack P. Antel
Journal of Neuroscience 27 April 2016, 36 (17) 4698-4707; DOI: 10.1523/JNEUROSCI.4077-15.2016
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Keywords

  • aerobic glycolysis
  • metabolic stress
  • multiple sclerosis
  • oligodendrocytes
  • oligodendrogliopathy

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