Article Information
- Received December 24, 2015
- Revision received March 3, 2016
- Accepted March 22, 2016
- First published April 27, 2016.
- Version of record published April 27, 2016.
Author Information
- Francesco Papaleo1,2,
- Feng Yang1,3,*,
- Clare Paterson4,*,
- Sara Palumbo1,5,
- Gregory V. Carr1,5,
- Yanhong Wang1,3,
- Kirsten Floyd4,
- Wenwei Huang6,
- Craig J. Thomas6,
- Jingshan Chen1,
- Daniel R. Weinberger1,3,7, and
- Amanda J. Law1,4,8
- 1Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892,
- 2Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, via Morego, 30, Genova 16163, Italy,
- 3Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, Maryland 21205,
- 4University of Colorado, School of Medicine, Department of Psychiatry, Aurora, Colorado 80045,
- 5Laboratory of Molecular Biology, Department of Surgical, Medical and Molecular Pathology and of Critical Care, University of Pisa, Pisa I-56126, Italy,
- 6National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850,
- 7Departments of Psychiatry, Neurology, and Neuroscience, and the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and
- 8University of Colorado, School of Medicine, Department of Cell and Developmental Biology, Aurora, Colorado 80045
Author contributions
Author contributions: F.P., F.Y., C.P., S.P., G.V.C., J.C., D.R.W., and A.J.L. designed research; F.P., F.Y., C.P., S.P., G.V.C., Y.W., K.F., J.C., and A.J.L. performed research; K.F., W.H., C.J.T., J.C., and D.R.W. contributed unpublished reagents/analytic tools; F.P., F.Y., C.P., S.P., G.V.C., Y.W., J.C., and A.J.L. analyzed data; F.P., J.C., D.R.W., and A.J.L. wrote the paper.
↵*F.Y. and C.P. contributed equally to this work.
Disclosures
- Received December 24, 2015.
- Revision received March 3, 2016.
- Accepted March 22, 2016.
This work was supported by funding from the National Institute of Mental Health (NIMH) Intramural Research Program, National Institutes of Health (NIH) to A.J.L and D.R.W., and by extramural funding from the NIH, NIMH to A.J.L (P50 MH-086383-06 and R01 MH103716-02). Support was also provided by the Sidney R. Baer, Jr. Award. Outstanding Research Achievement Prize for Schizophrenia Research from the Brain and Behavior Research Foundation/NARSAD and the Dr. Nancy Gary Endowed Chair in Children's Mental Health Disorders, both held by A.J.L. We thank Dr. James Pickel and the NIMH Division of Intramural Programs, Transgenic Core Facility for mouse oocyte injections, Mr. Qingjun Tian of NIMH, NIH for genotyping and mouse brain dissections and Dr. Wei Tan of NCI, NIH for original EF372273 construct synthesis.
The authors declare no competing financial interests.
- Correspondence should be addressed to Amanda J. Law, Departments of Psychiatry and Cell and Developmental Biology, University of Colorado, School of Medicine, 12700 East 19th Avenue, Mailstop 8619, RC2, Rm. 4100C, Aurora, Colorado 80045. amanda.law{at}ucdenver.edu
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