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Articles, Cellular/Molecular

Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model

Francesco Papaleo, Feng Yang, Clare Paterson, Sara Palumbo, Gregory V. Carr, Yanhong Wang, Kirsten Floyd, Wenwei Huang, Craig J. Thomas, Jingshan Chen, Daniel R. Weinberger and Amanda J. Law
Journal of Neuroscience 27 April 2016, 36 (17) 4859-4875; https://doi.org/10.1523/JNEUROSCI.4632-15.2016
Francesco Papaleo
1Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892,
2Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, via Morego, 30, Genova 16163, Italy,
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Feng Yang
1Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892,
3Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, Maryland 21205,
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Clare Paterson
4University of Colorado, School of Medicine, Department of Psychiatry, Aurora, Colorado 80045,
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Sara Palumbo
1Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892,
5Laboratory of Molecular Biology, Department of Surgical, Medical and Molecular Pathology and of Critical Care, University of Pisa, Pisa I-56126, Italy,
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Gregory V. Carr
1Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892,
5Laboratory of Molecular Biology, Department of Surgical, Medical and Molecular Pathology and of Critical Care, University of Pisa, Pisa I-56126, Italy,
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Yanhong Wang
1Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892,
3Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, Maryland 21205,
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Kirsten Floyd
4University of Colorado, School of Medicine, Department of Psychiatry, Aurora, Colorado 80045,
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Wenwei Huang
6National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850,
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Craig J. Thomas
6National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850,
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Jingshan Chen
1Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892,
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Daniel R. Weinberger
1Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892,
3Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, Maryland 21205,
7Departments of Psychiatry, Neurology, and Neuroscience, and the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and
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Amanda J. Law
1Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892,
4University of Colorado, School of Medicine, Department of Psychiatry, Aurora, Colorado 80045,
8University of Colorado, School of Medicine, Department of Cell and Developmental Biology, Aurora, Colorado 80045
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4632-15.2016
PubMed 
27122041
Published By 
Society for Neuroscience
History 
  • Received December 24, 2015
  • Revision received March 3, 2016
  • Accepted March 22, 2016
  • First published April 27, 2016.
  • Version of record published April 27, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/364860-17$15.00/0

Author Information

  1. Francesco Papaleo1,2,
  2. Feng Yang1,3,*,
  3. Clare Paterson4,*,
  4. Sara Palumbo1,5,
  5. Gregory V. Carr1,5,
  6. Yanhong Wang1,3,
  7. Kirsten Floyd4,
  8. Wenwei Huang6,
  9. Craig J. Thomas6,
  10. Jingshan Chen1,
  11. Daniel R. Weinberger1,3,7, and
  12. Amanda J. Law1,4,8
  1. 1Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892,
  2. 2Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, via Morego, 30, Genova 16163, Italy,
  3. 3Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, Maryland 21205,
  4. 4University of Colorado, School of Medicine, Department of Psychiatry, Aurora, Colorado 80045,
  5. 5Laboratory of Molecular Biology, Department of Surgical, Medical and Molecular Pathology and of Critical Care, University of Pisa, Pisa I-56126, Italy,
  6. 6National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850,
  7. 7Departments of Psychiatry, Neurology, and Neuroscience, and the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and
  8. 8University of Colorado, School of Medicine, Department of Cell and Developmental Biology, Aurora, Colorado 80045
View Full Text

Author contributions

  1. Author contributions: F.P., F.Y., C.P., S.P., G.V.C., J.C., D.R.W., and A.J.L. designed research; F.P., F.Y., C.P., S.P., G.V.C., Y.W., K.F., J.C., and A.J.L. performed research; K.F., W.H., C.J.T., J.C., and D.R.W. contributed unpublished reagents/analytic tools; F.P., F.Y., C.P., S.P., G.V.C., Y.W., J.C., and A.J.L. analyzed data; F.P., J.C., D.R.W., and A.J.L. wrote the paper.

  2. ↵*F.Y. and C.P. contributed equally to this work.

Disclosures

    • Received December 24, 2015.
    • Revision received March 3, 2016.
    • Accepted March 22, 2016.
  • This work was supported by funding from the National Institute of Mental Health (NIMH) Intramural Research Program, National Institutes of Health (NIH) to A.J.L and D.R.W., and by extramural funding from the NIH, NIMH to A.J.L (P50 MH-086383-06 and R01 MH103716-02). Support was also provided by the Sidney R. Baer, Jr. Award. Outstanding Research Achievement Prize for Schizophrenia Research from the Brain and Behavior Research Foundation/NARSAD and the Dr. Nancy Gary Endowed Chair in Children's Mental Health Disorders, both held by A.J.L. We thank Dr. James Pickel and the NIMH Division of Intramural Programs, Transgenic Core Facility for mouse oocyte injections, Mr. Qingjun Tian of NIMH, NIH for genotyping and mouse brain dissections and Dr. Wei Tan of NCI, NIH for original EF372273 construct synthesis.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Amanda J. Law, Departments of Psychiatry and Cell and Developmental Biology, University of Colorado, School of Medicine, 12700 East 19th Avenue, Mailstop 8619, RC2, Rm. 4100C, Aurora, Colorado 80045. amanda.law{at}ucdenver.edu

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The Journal of Neuroscience: 36 (17)
Journal of Neuroscience
Vol. 36, Issue 17
27 Apr 2016
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Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model
Francesco Papaleo, Feng Yang, Clare Paterson, Sara Palumbo, Gregory V. Carr, Yanhong Wang, Kirsten Floyd, Wenwei Huang, Craig J. Thomas, Jingshan Chen, Daniel R. Weinberger, Amanda J. Law
Journal of Neuroscience 27 April 2016, 36 (17) 4859-4875; DOI: 10.1523/JNEUROSCI.4632-15.2016

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Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model
Francesco Papaleo, Feng Yang, Clare Paterson, Sara Palumbo, Gregory V. Carr, Yanhong Wang, Kirsten Floyd, Wenwei Huang, Craig J. Thomas, Jingshan Chen, Daniel R. Weinberger, Amanda J. Law
Journal of Neuroscience 27 April 2016, 36 (17) 4859-4875; DOI: 10.1523/JNEUROSCI.4632-15.2016
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Keywords

  • Akt
  • erbB
  • IC87114
  • Neuregulin
  • PIK3CD
  • schizophrenia

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