Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model

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¹Clinical Brain Disorders Branch, Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892,
²Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, via Morego, 30, Genova 16163, Italy,
³Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, Maryland 21205,
⁴University of Colorado, School of Medicine, Department of Psychiatry, Aurora, Colorado 80045,
⁵Laboratory of Molecular Biology, Department of Surgical, Medical and Molecular Pathology and of Critical Care, University of Pisa, Pisa I-56126, Italy,
⁶National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850,
⁷Departments of Psychiatry, Neurology, and Neuroscience, and the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, and
⁸University of Colorado, School of Medicine, Department of Cell and Developmental Biology, Aurora, Colorado 80045

Author contributions: F.P., F.Y., C.P., S.P., G.V.C., J.C., D.R.W., and A.J.L. designed research; F.P., F.Y., C.P., S.P., G.V.C., Y.W., K.F., J.C., and A.J.L. performed research; K.F., W.H., C.J.T., J.C., and D.R.W. contributed unpublished reagents/analytic tools; F.P., F.Y., C.P., S.P., G.V.C., Y.W., J.C., and A.J.L. analyzed data; F.P., J.C., D.R.W., and A.J.L. wrote the paper.
↵*F.Y. and C.P. contributed equally to this work.

This work was supported by funding from the National Institute of Mental Health (NIMH) Intramural Research Program, National Institutes of Health (NIH) to A.J.L and D.R.W., and by extramural funding from the NIH, NIMH to A.J.L (P50 MH-086383-06 and R01 MH103716-02). Support was also provided by the Sidney R. Baer, Jr. Award. Outstanding Research Achievement Prize for Schizophrenia Research from the Brain and Behavior Research Foundation/NARSAD and the Dr. Nancy Gary Endowed Chair in Children's Mental Health Disorders, both held by A.J.L. We thank Dr. James Pickel and the NIMH Division of Intramural Programs, Transgenic Core Facility for mouse oocyte injections, Mr. Qingjun Tian of NIMH, NIH for genotyping and mouse brain dissections and Dr. Wei Tan of NCI, NIH for original EF372273 construct synthesis.
The authors declare no competing financial interests.
Correspondence should be addressed to Amanda J. Law, Departments of Psychiatry and Cell and Developmental Biology, University of Colorado, School of Medicine, 12700 East 19th Avenue, Mailstop 8619, RC2, Rm. 4100C, Aurora, Colorado 80045. amanda.law{at}ucdenver.edu

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