Article Information
- Received July 14, 2014
- Revision received October 29, 2015
- Accepted November 10, 2015
- First published January 12, 2016.
- Version of record published January 12, 2016.
Author Information
- Clair A. Booth1,*,
- Thomas Ridler2,*,
- Tracey K. Murray3,
- Mark A. Ward3,
- Emily de Groot2,
- Marc Goodfellow4,
- Keith G. Phillips3,
- Andrew D. Randall1,2, and
- Jonathan T. Brown1,2
- 1School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, United Kingdom,
- 2Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Hatherly Laboratories, Exeter EX4 4PS, United Kingdom,
- 3Lilly UK, Windlesham, Surrey GU20 6PH, United Kingdom, and
- 4College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter EX4 4SB, United Kingdom
Author contributions
Author contributions: M.G., A.D.R., and J.T.B. designed research; C.A.B., T.R., T.K.M., M.A.W., and E.d.G. performed research; K.G.P. contributed unpublished reagents/analytic tools; C.A.B., T.R., T.K.M., M.A.W., and J.T.B. analyzed data; J.T.B. wrote the paper.
↵*C.A.B. and T.R. contributed equally to this work.
Disclosures
- Received July 14, 2014.
- Revision received October 29, 2015.
- Accepted November 10, 2015.
C.A.B. was funded by an MRC-CASE studentship co-funded by Pfizer. T.R. was funded by a University of Exeter and Eli Lilly studentship. T.K.M., M.A.W., and K.G.P. were employees of Eli Lilly. A.D.R. was funded by a Royal Society Industrial Fellowship. J.T.B. was an Alzheimer's Research UK Senior Research Fellow. M.G. and J.T.B. were additionally supported by “Bridging the gaps” funding via the University of Exeter. Eli Lilly provided the rTg4510 mice. We thank H. Hardy and P. Leete for assistance with microscopy.
The authors declare no competing financial interests.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
- Correspondence should be addressed to Jonathan T. Brown, Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Hatherly Laboratories, Prince of Wales Road, Exeter EX4 4PS, UK. J.T.Brown{at}exeter.ac.uk
