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Articles, Development/Plasticity/Repair

Death Domain Signaling by Disulfide-Linked Dimers of the p75 Neurotrophin Receptor Mediates Neuronal Death in the CNS

Kazuhiro Tanaka, Claire E. Kelly, Ket Yin Goh, Kim Buay Lim and Carlos F. Ibáñez
Journal of Neuroscience 18 May 2016, 36 (20) 5587-5595; https://doi.org/10.1523/JNEUROSCI.4536-15.2016
Kazuhiro Tanaka
1Department of Physiology, National University of Singapore, Singapore 117597, Singapore,
2Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore,
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Claire E. Kelly
3Department of Neuroscience, Karolinska Institute, Stockholm S-17177, Sweden, and
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Ket Yin Goh
1Department of Physiology, National University of Singapore, Singapore 117597, Singapore,
2Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore,
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Kim Buay Lim
1Department of Physiology, National University of Singapore, Singapore 117597, Singapore,
2Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore,
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Carlos F. Ibáñez
1Department of Physiology, National University of Singapore, Singapore 117597, Singapore,
2Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore,
3Department of Neuroscience, Karolinska Institute, Stockholm S-17177, Sweden, and
4Stellenbosch Institute for Advanced Study, Wallenberg Research Centre at Stellenbosch University, Stellenbosch 7600, South Africa
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4536-15.2016
PubMed 
27194337
Published By 
Society for Neuroscience
History 
  • Received December 20, 2015
  • Revision received April 11, 2016
  • Accepted April 12, 2016
  • First published May 18, 2016.
  • Version of record published May 18, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/365587-09$15.00/0

Author Information

  1. Kazuhiro Tanaka1,2,
  2. Claire E. Kelly3,
  3. Ket Yin Goh1,2,
  4. Kim Buay Lim1,2, and
  5. Carlos F. Ibáñez1,2,3,4
  1. 1Department of Physiology, National University of Singapore, Singapore 117597, Singapore,
  2. 2Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore,
  3. 3Department of Neuroscience, Karolinska Institute, Stockholm S-17177, Sweden, and
  4. 4Stellenbosch Institute for Advanced Study, Wallenberg Research Centre at Stellenbosch University, Stellenbosch 7600, South Africa
View Full Text

Author contributions

  1. Author contributions: K.T. and C.F.I. designed research; K.T., C.E.K., K.Y.G., and K.B.L. performed research; K.T., C.E.K., and C.F.I. analyzed data; K.T. and C.F.I. wrote the paper.

Disclosures

    • Received December 20, 2015.
    • Revision received April 11, 2016.
    • Accepted April 12, 2016.
  • This work was supported by the National Medical Research Council of Singapore (Grant CBRG13nov012), the Ministry of Education of Singapore (Grant MOE2014-T2-1-120), the National University of Singapore (Start-Up and Strategic ODPRT Awards), the European Research Council (Grant 339237-p75ntr), the Swedish Research Council (Grant K2012-63X-10908-19-5), the Swedish Cancer Society (Grant 13-0676), and the Knut and Alice Wallenberg Foundation (Grant KAW 2012.0270). We thank Wilma Friedman for reading and commenting on the manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Carlos F. Ibáñez, Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore. phscfi{at}nus.edu.sg

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Total 202559311179
Total51921121129
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The Journal of Neuroscience: 36 (20)
Journal of Neuroscience
Vol. 36, Issue 20
18 May 2016
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Death Domain Signaling by Disulfide-Linked Dimers of the p75 Neurotrophin Receptor Mediates Neuronal Death in the CNS
Kazuhiro Tanaka, Claire E. Kelly, Ket Yin Goh, Kim Buay Lim, Carlos F. Ibáñez
Journal of Neuroscience 18 May 2016, 36 (20) 5587-5595; DOI: 10.1523/JNEUROSCI.4536-15.2016

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Death Domain Signaling by Disulfide-Linked Dimers of the p75 Neurotrophin Receptor Mediates Neuronal Death in the CNS
Kazuhiro Tanaka, Claire E. Kelly, Ket Yin Goh, Kim Buay Lim, Carlos F. Ibáñez
Journal of Neuroscience 18 May 2016, 36 (20) 5587-5595; DOI: 10.1523/JNEUROSCI.4536-15.2016
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Keywords

  • apoptosis
  • disulfide bond
  • epilepsy
  • neurotrophins
  • seizures

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