Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice

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¹Clem Jones Centre for Ageing Dementia Research,
²Queensland Brain Institute,
³Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, QLD 4072, Australia, and
⁴Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92617

Author contributions: J.W., Q.-Y.Z., V.A., and T.W.B. designed research; J.W., Q.-Y.Z., M.-J.K., M.C.T., V.S.R., W.W., L.L., P.A.S., and J.E. performed research; J.W. contributed unpublished reagents/analytic tools; J.W., Q.-Y.Z., M.-J.K., and V.A. analyzed data; J.W., Q.-Y.Z., V.A., and T.W.B. wrote the paper.
↵*J.W. and Q.-Y.Z. contributed equally to this work.

This work was supported by grants from the National Institutes of Mental Health (1R01MH109588-01 to T.W.B.), Australian National Health and Medical Research Council (APP1042051 and APP1062570 to T.W.B.), the Australian Research Council (DP1096148 to T.W.B.), and the John T. Reid Charitable Trusts (to V.A.); a fellowship from the Australian National Health and Medical Research Council (477108 to V.A.); and postgraduate scholarships from the Australian Government and Queensland Brain Institute, The University of Queensland to P.A.S. We thank Dr. Danay Baker-Andresen for assisting with behavioral experiments and Rowan Tweedale for helpful editing of this paper.
The authors declare no competing financial interests.
Correspondence should be addressed to either of the following: Dr. Jocelyn Widagdo, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia, j.widagdo{at}uq.edu.au; or Dr. Timothy W. Bredy, Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92617. tbredy{at}uci.edu

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