Article Information
- Received January 23, 2016
- Revision received June 26, 2016
- Accepted June 29, 2016
- First published August 24, 2016.
- Version of record published August 24, 2016.
Author Information
- Robbert Havekes1,2,
- Alan J. Park2,
- Rosa E. Tolentino3,
- Vibeke M. Bruinenberg1,
- Jennifer C. Tudor2,
- Yool Lee3,
- Rolf T. Hansen2,
- Leonardo A. Guercio2,
- Edward Linton2,
- Susana R. Neves-Zaph4,
- Peter Meerlo1,
- George S. Baillie5,
- Miles D. Houslay6, and
- Ted Abel2
- 1Groningen Institute for Evolutionary Life Sciences, University of Groningen, 9700 AB, Groningen, The Netherlands,
- 2Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104,
- 3Department of Systems Pharmacology and Translational Therapeutics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104,
- 4Departments of Pharmacology and Systems Therapeutics, Friedman Brain Institute, and System Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, New York 10029,
- 5Institute of Cardiovascular and Medical Science, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom, and
- 6Institute of Pharmaceutical Science, King's College London, London SE1 9NH, United Kingdom
Author contributions
Author contributions: R.H., A.J.P., J.C.T., R.T.H., S.R.N.-Z., P.M., G.S.B., M.D.H., and T.A. designed research; R.H., A.J.P., R.E.T., V.M.B., J.C.T., Y.L., L.A.G., and E.L. performed research; G.S.B. and M.D.H. contributed unpublished reagents/analytic tools; R.H., A.J.P., R.E.T., V.M.B., J.C.T., and S.R.N.-Z. analyzed data; R.H., P.M., M.D.H., and T.A. wrote the paper.
Disclosures
- Received January 23, 2016.
- Revision received June 26, 2016.
- Accepted June 29, 2016.
This research was supported by Netherlands Organization for Scientific Research NWO-Rubicon Grant 825.07.029 (to R.H.); the University of Pennsylvania Research Foundation (to R.H. and T.A.); National Institutes of Health Grants 1R01-MH-086415 9 (to T.A.), AG-017628 (to T.A., A.I. Pack Principal Investigator), 5K12-GM-081529 (to J.C.T., Y. Paterson Principal Investigator), and 5R01-DK-087650 (to S.R.N.-Z.); and Systems Biology Center of New York Grant PSDGM071558 (to S.R.N.-Z.). G.S.B. is supported by Medical Research Council Grant MR/J007412/1. R.H. is supported by the Einsteinium Foundation. T.A. is the Brush Family Professor of Biology at the University of Pennsylvania. We thank other Abel laboratory members for their help with these experiments and for their comments on this manuscript. We also thank Jin Zhang for providing pICUE3.
The authors declare no competing financial interests.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
- Correspondence should be addressed to either of the following: Robbert Havekes, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, 9700 AB, Groningen, The Netherlands, r.havekes{at}rug.nl; or Ted Abel, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018. abele{at}sas.upenn.edu
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