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Featured ArticleArticles, Development/Plasticity/Repair

ERK1/2 Activation in Preexisting Oligodendrocytes of Adult Mice Drives New Myelin Synthesis and Enhanced CNS Function

Marisa A. Jeffries, Kelly Urbanek, Lester Torres, Stacy Gelhaus Wendell, Maria E. Rubio and Sharyl L. Fyffe-Maricich
Journal of Neuroscience 31 August 2016, 36 (35) 9186-9200; DOI: https://doi.org/10.1523/JNEUROSCI.1444-16.2016
Marisa A. Jeffries
1Center for Neuroscience,
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  • ORCID record for Marisa A. Jeffries
Kelly Urbanek
2Department of Pediatrics, Division of Neurology, and
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Lester Torres
3Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania 15224, and
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Stacy Gelhaus Wendell
4Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
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Maria E. Rubio
1Center for Neuroscience,
3Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania 15224, and
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Sharyl L. Fyffe-Maricich
1Center for Neuroscience,
2Department of Pediatrics, Division of Neurology, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1444-16.2016
PubMed 
27581459
Published By 
Society for Neuroscience
History 
  • Received May 2, 2016
  • Revision received July 11, 2016
  • Accepted July 20, 2016
  • First published August 31, 2016.
  • Version of record published August 31, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/369186-15$15.00/0

Author Information

  1. Marisa A. Jeffries1,
  2. Kelly Urbanek2,
  3. Lester Torres3,
  4. Stacy Gelhaus Wendell4,
  5. Maria E. Rubio1,3, and
  6. Sharyl L. Fyffe-Maricich1,2
  1. 1Center for Neuroscience,
  2. 2Department of Pediatrics, Division of Neurology, and
  3. 3Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania 15224, and
  4. 4Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261
View Full Text

Author contributions

  1. Author contributions: M.A.J., M.E.R., and S.L.F.-M. designed research; M.A.J., K.U., L.T., S.G.W., and S.L.F.-M. performed research; M.A.J., L.T., S.G.W., M.E.R., and S.L.F.-M. analyzed data; M.A.J. and S.L.F.-M. wrote the paper.

Disclosures

    • Received May 2, 2016.
    • Revision received July 11, 2016.
    • Accepted July 20, 2016.
  • This work was supported by the National Institutes of Health (Grant 1S10OD016236-01 to the Center for Biologic Imaging at the University of Pittsburgh, a National Multiple Sclerosis Society Career-Transition Fellowship to S.F-M., Grant R01 NS091084 to S.F.-M., and National Institute on Deafness and Other Communication Disorders Grant 013048 to M.R.) We thank Mara Sullivan and the Center for Biologic Imaging at University of Pittsburgh for assistance in obtaining transmission EM sections and images; Laura Miller, Edda Thiels, and the Rodent Behavioral Analysis Core at the University of Pittsburgh for assistance in performing behavior tests and analyzing data; Luther Loose and Shil Patel for technical assistance in experiments; and Stephen Maricich, Jenna Gaesser, and Lilly Laemmle for helpful discussions and comments on this manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Sharyl L. Fyffe-Maricich, University of Pittsburgh, One Children's Hospital Dr., 4401 Penn Ave., RRB Rm 3512, Pittsburgh, PA 15224. sharyl.fyffemaricich{at}chp.edu.

Online Impact

 

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Article usage: August 2016 to April 2022

AbstractFullPdf
Aug 20168341286
Sep 20162064152189
Oct 20162346264
Nov 20161723317
Dec 20161532621
Total 20163457285377
Jan 20171253521
Feb 20171972313
Mar 20171207721
Apr 2017375112
May 2017326012
Jun 2017154410
Jul 2017113717
Aug 2017144523
Sep 2017205223
Oct 2017685016
Nov 2017785420
Dec 2017415123
Total 2017758579211
Jan 2018354012
Feb 2018464015
Mar 201876021
Apr 201875019
May 2018136627
Jun 201865122
Jul 201822716
Aug 2018143013
Sep 2018134823
Oct 2018143418
Nov 201864025
Dec 2018133213
Total 2018176518224
Jan 201913409
Feb 201944321
Mar 2019396230
Apr 2019433122
May 2019156530
Jun 2019103118
Jul 201962516
Aug 201952529
Sep 2019103317
Oct 2019223020
Nov 2019232416
Dec 2019141417
Total 2019204423245
Jan 2020153021
Feb 2020182819
Mar 202054322
Apr 202093943
May 202093016
Jun 202031621
Jul 20203199
Aug 202062220
Sep 2020103520
Oct 2020115328
Nov 2020195831
Dec 202045218
Total 2020112425268
Jan 20218305
Feb 202193116
Mar 2021195013
Apr 202163913
May 202164416
Jun 202144116
Jul 2021133526
Aug 202124521
Sep 202112308
Oct 2021124634
Nov 2021126045
Dec 2021144913
Total 2021104900226
Jan 20221190636
Feb 2022210868
Mar 202232813
Apr 202283319
Total 202224205376
Total483551831627
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The Journal of Neuroscience: 36 (35)
Journal of Neuroscience
Vol. 36, Issue 35
31 Aug 2016
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ERK1/2 Activation in Preexisting Oligodendrocytes of Adult Mice Drives New Myelin Synthesis and Enhanced CNS Function
Marisa A. Jeffries, Kelly Urbanek, Lester Torres, Stacy Gelhaus Wendell, Maria E. Rubio, Sharyl L. Fyffe-Maricich
Journal of Neuroscience 31 August 2016, 36 (35) 9186-9200; DOI: 10.1523/JNEUROSCI.1444-16.2016

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ERK1/2 Activation in Preexisting Oligodendrocytes of Adult Mice Drives New Myelin Synthesis and Enhanced CNS Function
Marisa A. Jeffries, Kelly Urbanek, Lester Torres, Stacy Gelhaus Wendell, Maria E. Rubio, Sharyl L. Fyffe-Maricich
Journal of Neuroscience 31 August 2016, 36 (35) 9186-9200; DOI: 10.1523/JNEUROSCI.1444-16.2016
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Keywords

  • ERK MAP kinase
  • intracellular signaling
  • myelin
  • myelin plasticity
  • oligodendrocyte
  • remyelination

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