Article Information
- Received February 11, 2016
- Revision received June 21, 2016
- Accepted July 14, 2016
- First published September 7, 2016.
- Version of record published September 7, 2016.
Author Information
- Mahtab A. Khan1,*,
- Sina Schultz1,*,
- Alaa Othman1,2,
- Thomas Fleming4,
- Rafael Lebrón-Galán5,
- Dirk Rades3,
- Diego Clemente5,
- Peter P. Nawroth4, and
- Markus Schwaninger1,6
- 1Institute of Experimental and Clinical Pharmacology and Toxicology,
- 2Core facility for bioanalysis and mass spectrometry, Center of Brain, Behavior and Metabolism, and
- 3Department of Radiation Oncology, University of Lübeck, 23562 Lübeck, Germany,
- 4Department of Internal Medicine, University of Heidelberg, 69120 Heidelberg, Germany,
- 5Grupo de Neuroimmuno-Reparación, Hospital Nacional de Parapléjicos, 45071 Toledo, Spain, and
- 6German Research Centre for Cardiovascular Research, 23562 Lübeck, Germany
Author contributions
Author contributions: M.A.K., S.S., and M.S. designed research; M.A.K., S.S., A.O., R.L.-G., D.R., and D.C. performed research; T.F. and P.P.N. contributed unpublished reagents/analytic tools; M.A.K., S.S., A.O., R.L.-G., D.C., and M.S. analyzed data; M.A.K., S.S., T.F., D.C., P.P.N., and M.S. wrote the paper.
↵*M.A.K. and S.S. contributed equally to this work.
Disclosures
- Received February 11, 2016.
- Revision received June 21, 2016.
- Accepted July 14, 2016.
The research leading to these results received funding from the Deutsche Forschungsgemeinschaft (Grant SCHW 413/7-1 to M.S. and Grant SFB 1118 to P.P.N. and T.F.) and the Spanish Ministerio de Economia y Competitividad (partially financed by FEDER; European Union “Una manera de hacer Europa”; Grant PI15/00963 to D.C.). We thank Prof. Dr Arnold von Eckardstein and Dr. Thorsten Hornemann for providing access to their mass spectrometry laboratory at the Institute of Clinical Chemistry, University of Zurich, during the early phases of the LC/MS method development for dicarbonyl measurement and Dr. Rodríguez-Alfaro and Dr. Mazarío for help with the confocal imaging.
The authors declare no competing financial interests.
- Correspondence should be addressed to Markus Schwaninger, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. markus.schwaninger{at}pharma.uni-luebeck.de
