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Articles, Systems/Circuits

Engagement of the Rat Hindlimb Motor Cortex across Natural Locomotor Behaviors

Jack DiGiovanna, Nadia Dominici, Lucia Friedli, Jacopo Rigosa, Simone Duis, Julie Kreider, Janine Beauparlant, Rubia van den Brand, Marco Schieppati, Silvestro Micera and Grégoire Courtine
Journal of Neuroscience 5 October 2016, 36 (40) 10440-10455; https://doi.org/10.1523/JNEUROSCI.4343-15.2016
Jack DiGiovanna
1Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne 1005, Switzerland,
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Nadia Dominici
2International Paraplegic Foundation Chair Spinal Cord Repair, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne 1015, Switzerland,
3MOVE Research Institute Amsterdam, Department of Human Movement Sciences, VU University Amsterdam, Amsterdam 1081 HV, The Netherlands,
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Lucia Friedli
2International Paraplegic Foundation Chair Spinal Cord Repair, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne 1015, Switzerland,
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Jacopo Rigosa
1Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne 1005, Switzerland,
4Translational Neural Engineering Area, The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa 56127, Italy, and
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Simone Duis
2International Paraplegic Foundation Chair Spinal Cord Repair, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne 1015, Switzerland,
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Julie Kreider
2International Paraplegic Foundation Chair Spinal Cord Repair, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne 1015, Switzerland,
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Janine Beauparlant
2International Paraplegic Foundation Chair Spinal Cord Repair, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne 1015, Switzerland,
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Rubia van den Brand
2International Paraplegic Foundation Chair Spinal Cord Repair, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne 1015, Switzerland,
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Marco Schieppati
5Department of Public Health, Experimental and Forensic Medicine, University of Pavia, and Fondazione Salvatore Maugeri (IRCCS), Centro Studi Attività Motorie (CSAM), Pavia 27100, Italy
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Silvestro Micera
1Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne 1005, Switzerland,
4Translational Neural Engineering Area, The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa 56127, Italy, and
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Grégoire Courtine
2International Paraplegic Foundation Chair Spinal Cord Repair, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne 1015, Switzerland,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.4343-15.2016
PubMed 
27707977
Published By 
Society for Neuroscience
History 
  • Received December 2, 2015
  • Revision received August 21, 2016
  • Accepted August 23, 2016
  • First published October 5, 2016.
  • Version of record published October 5, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/3610440-16$15.00/0

Author Information

  1. Jack DiGiovanna1,*,
  2. Nadia Dominici2,3,*,
  3. Lucia Friedli2,
  4. Jacopo Rigosa1,4,
  5. Simone Duis2,
  6. Julie Kreider2,
  7. Janine Beauparlant2,
  8. Rubia van den Brand2,
  9. Marco Schieppati5,
  10. Silvestro Micera1,4,†, and
  11. Grégoire Courtine2,†
  1. 1Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne 1005, Switzerland,
  2. 2International Paraplegic Foundation Chair Spinal Cord Repair, Center for Neuroprosthetics and Brain Mind Institute, Swiss Federal Institute of Technology (EPFL), Lausanne 1015, Switzerland,
  3. 3MOVE Research Institute Amsterdam, Department of Human Movement Sciences, VU University Amsterdam, Amsterdam 1081 HV, The Netherlands,
  4. 4Translational Neural Engineering Area, The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa 56127, Italy, and
  5. 5Department of Public Health, Experimental and Forensic Medicine, University of Pavia, and Fondazione Salvatore Maugeri (IRCCS), Centro Studi Attività Motorie (CSAM), Pavia 27100, Italy
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Author contributions

  1. Author contributions: J.D., M.S., S.M., and G.C. designed research; J.D., N.D., L.F., S.D., J.K., J.B., and R.v.d.B. performed research; J.D., N.D., J.R., and J.K. contributed unpublished reagents/analytic tools; J.D., N.D., J.R., J.B., and G.C. analyzed data; J.D., M.S., and G.C. wrote the paper.

  2. ↵*J.D. and N.D. contributed equally to this work.

  3. ↵†S.M. and G.C. contributed equally to this work.

Disclosures

    • Received December 2, 2015.
    • Revision received August 21, 2016.
    • Accepted August 23, 2016.
  • This work was supported by European Research Council Starting Grant ERC 261247, Walk Again, European Community's Seventh Framework Program CP-IP 258654, NeuWALK, and the National Center of Competence in Research in Robotics. We thank Michelle Hürlimann for behavioral training and recording; Jean Laurens for helpful feedback on the manuscript; Alessandro Panarese for assistance with the preprocessing architecture for spike sorting; and Joachim von Zitzewitz for 3D rat rendering.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either of the following: Dr. Jack DiGiovanna, EPFL STI CNP TNE, BM 3114-5-6 (Bâtiment BM), Station 17, CH-1015 Lausanne, Switzerland. jack.digiovanna{at}gmail.com; or Dr. Grégoire Courtine, EPFL SV BMI UPCOURTINE, Office: AI 1240, Station 19, CH-1015 Lausanne, Switzerland. gregoire.courtine{at}epfl.ch

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The Journal of Neuroscience: 36 (40)
Journal of Neuroscience
Vol. 36, Issue 40
5 Oct 2016
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Engagement of the Rat Hindlimb Motor Cortex across Natural Locomotor Behaviors
Jack DiGiovanna, Nadia Dominici, Lucia Friedli, Jacopo Rigosa, Simone Duis, Julie Kreider, Janine Beauparlant, Rubia van den Brand, Marco Schieppati, Silvestro Micera, Grégoire Courtine
Journal of Neuroscience 5 October 2016, 36 (40) 10440-10455; DOI: 10.1523/JNEUROSCI.4343-15.2016

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Engagement of the Rat Hindlimb Motor Cortex across Natural Locomotor Behaviors
Jack DiGiovanna, Nadia Dominici, Lucia Friedli, Jacopo Rigosa, Simone Duis, Julie Kreider, Janine Beauparlant, Rubia van den Brand, Marco Schieppati, Silvestro Micera, Grégoire Courtine
Journal of Neuroscience 5 October 2016, 36 (40) 10440-10455; DOI: 10.1523/JNEUROSCI.4343-15.2016
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Keywords

  • kinematics
  • locomotion
  • motor cortex
  • muscle synergies
  • neural ensemble
  • rat

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