This image shows a wide-field view of deconvolved hippocampal synapses, defined by the postsynaptic protein PSD-95 (green). A subgroup of these synapses co-express visible levels of RhoA (red), and thus appear yellow. RhoA is a member of the Rho-GTPase family of enzymes and contributes to the stability of the actin skeleton of synapses and dendritic spines. During multiple acute stresses, the combined actions of the adrenal stress hormone corticosterone and hippocampal-origin CRH reduce the levels of active RhoA within hippocampal synapses, promoting their collapse. For more information, see the article by Chen et al. (pages 11295–11307).