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Cover ArticleResearch Articles, Development/Plasticity/Repair

Converging, Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses

Yuncai Chen, Jenny Molet, Julie C. Lauterborn, Brian H. Trieu, Jessica L. Bolton, Katelin P. Patterson, Christine M. Gall, Gary Lynch and Tallie Z. Baram
Journal of Neuroscience 2 November 2016, 36 (44) 11295-11307; https://doi.org/10.1523/JNEUROSCI.2542-16.2016
Yuncai Chen
1Department of Anatomy/Neurobiology,
2Department of Pediatrics, and
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Jenny Molet
1Department of Anatomy/Neurobiology,
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Julie C. Lauterborn
1Department of Anatomy/Neurobiology,
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Brian H. Trieu
1Department of Anatomy/Neurobiology,
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Jessica L. Bolton
1Department of Anatomy/Neurobiology,
2Department of Pediatrics, and
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Katelin P. Patterson
1Department of Anatomy/Neurobiology,
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Christine M. Gall
1Department of Anatomy/Neurobiology,
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Gary Lynch
1Department of Anatomy/Neurobiology,
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Tallie Z. Baram
1Department of Anatomy/Neurobiology,
2Department of Pediatrics, and
3Department of Neurology, University of California–Irvine, Irvine, California 92697
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2542-16.2016
PubMed 
27807170
Published By 
Society for Neuroscience
History 
  • Received August 10, 2016
  • Revision received September 3, 2016
  • Accepted September 16, 2016
  • First published November 2, 2016.
  • Version of record published November 2, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/3611295-13$15.00/0

Author Information

  1. Yuncai Chen1,2,
  2. Jenny Molet1,
  3. Julie C. Lauterborn1,
  4. Brian H. Trieu1,
  5. Jessica L. Bolton1,2,
  6. Katelin P. Patterson1,
  7. Christine M. Gall1,
  8. Gary Lynch1, and
  9. Tallie Z. Baram1,2,3
  1. 1Department of Anatomy/Neurobiology,
  2. 2Department of Pediatrics, and
  3. 3Department of Neurology, University of California–Irvine, Irvine, California 92697
View Full Text

Author contributions

  1. Author contributions: Y.C., G.L., and T.Z.B. designed research; Y.C., J.M., J.C.L., B.H.T., J.L.B., and K.P.P. performed research; C.M.G. contributed unpublished reagents/analytic tools; Y.C., J.M., J.C.L., B.H.T., J.L.B., and G.L. analyzed data; Y.C., C.M.G., G.L., and T.Z.B. wrote the paper.

Disclosures

    • Received August 10, 2016.
    • Revision received September 3, 2016.
    • Accepted September 16, 2016.
  • This work was supported by the National Institutes of Health (Grants P50 MH096889, NS28912, and NS45260) and the Hewitt Foundation for Biomedical Research. We thank Ben Gunn for excellent discussions.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Tallie Z. Baram, MD, PhD, or Yuncai Chen, PhD, Department of Anatomy/Neurobiology and Department of Pediatrics, University of California-Irvine, Medical Sciences I, ZOT: 4475, Irvine, CA 92697-4475. tallie{at}uci.edu or yuncaic{at}uci.edu

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Jun 2025341
Total 20257114672
Total87238051133
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The Journal of Neuroscience: 36 (44)
Journal of Neuroscience
Vol. 36, Issue 44
2 Nov 2016
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Converging, Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses
Yuncai Chen, Jenny Molet, Julie C. Lauterborn, Brian H. Trieu, Jessica L. Bolton, Katelin P. Patterson, Christine M. Gall, Gary Lynch, Tallie Z. Baram
Journal of Neuroscience 2 November 2016, 36 (44) 11295-11307; DOI: 10.1523/JNEUROSCI.2542-16.2016

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Converging, Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses
Yuncai Chen, Jenny Molet, Julie C. Lauterborn, Brian H. Trieu, Jessica L. Bolton, Katelin P. Patterson, Christine M. Gall, Gary Lynch, Tallie Z. Baram
Journal of Neuroscience 2 November 2016, 36 (44) 11295-11307; DOI: 10.1523/JNEUROSCI.2542-16.2016
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Keywords

  • acute stress
  • dendritic spine
  • hippocampus
  • long-term potentiation
  • memory
  • RhoGTPase

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