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Research Articles, Neurobiology of Disease

Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice

Chul Han, Dalian Ding, Maria-Cecilia Lopez, Senthilvelan Manohar, Yanping Zhang, Mi-Jung Kim, Hyo-Jin Park, Karessa White, Yong Hwan Kim, Paul Linser, Masaru Tanokura, Christiaan Leeuwenburgh, Henry V. Baker, Richard J. Salvi and Shinichi Someya
Journal of Neuroscience 2 November 2016, 36 (44) 11308-11319; DOI: https://doi.org/10.1523/JNEUROSCI.2493-16.2016
Chul Han
1Department of Aging and Geriatric Research,
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Dalian Ding
6Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York 14214, and
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Maria-Cecilia Lopez
2Department of Molecular Genetics and Microbiology,
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Senthilvelan Manohar
6Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York 14214, and
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Yanping Zhang
3Gene Expression and Genotyping, Interdisciplinary Center for Biotechnology Research, and
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Mi-Jung Kim
1Department of Aging and Geriatric Research,
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Hyo-Jin Park
1Department of Aging and Geriatric Research,
5Whitney Laboratory, University of Florida, St. Augustine, Florida 32080,
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Karessa White
1Department of Aging and Geriatric Research,
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Yong Hwan Kim
4Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32610,
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Paul Linser
5Whitney Laboratory, University of Florida, St. Augustine, Florida 32080,
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Masaru Tanokura
7Department of Applied Biological Chemistry, University of Tokyo, Yayoi, Tokyo, 113, Japan
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Christiaan Leeuwenburgh
1Department of Aging and Geriatric Research,
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Henry V. Baker
2Department of Molecular Genetics and Microbiology,
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Richard J. Salvi
6Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York 14214, and
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Shinichi Someya
1Department of Aging and Geriatric Research,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2493-16.2016
PubMed 
27807171
Published By 
Society for Neuroscience
History 
  • Received August 5, 2016
  • Revision received September 9, 2016
  • Accepted September 15, 2016
  • First published November 2, 2016.
  • Version of record published November 2, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/3611308-12$15.00/0

Author Information

  1. Chul Han1,
  2. Dalian Ding6,
  3. Maria-Cecilia Lopez2,
  4. Senthilvelan Manohar6,
  5. Yanping Zhang3,
  6. Mi-Jung Kim1,
  7. Hyo-Jin Park1,5,
  8. Karessa White1,
  9. Yong Hwan Kim4,
  10. Paul Linser5,
  11. Masaru Tanokura7,
  12. Christiaan Leeuwenburgh1,
  13. Henry V. Baker2,
  14. Richard J. Salvi6, and
  15. Shinichi Someya1
  1. 1Department of Aging and Geriatric Research,
  2. 2Department of Molecular Genetics and Microbiology,
  3. 3Gene Expression and Genotyping, Interdisciplinary Center for Biotechnology Research, and
  4. 4Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida 32610,
  5. 5Whitney Laboratory, University of Florida, St. Augustine, Florida 32080,
  6. 6Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, New York 14214, and
  7. 7Department of Applied Biological Chemistry, University of Tokyo, Yayoi, Tokyo, 113, Japan
View Full Text

Author contributions

  1. Author contributions: C.H., H.V.B., and S.S. designed research; C.H., D.D., M.-C.L., S.M., Y.Z., M.-J.K., H.-J.P., K.W., Y.H.K., and P.L. performed research; P.L., M.T., C.L., and R.J.S. contributed unpublished reagents/analytic tools; C.H., D.D., M.-C.L., S.M., Y.Z., M.-J.K., H.-J.P., K.W., Y.H.K., H.V.B., R.J.S., and S.S. analyzed data; C.H., M.T., C.L., H.V.B., R.J.S., and S.S. wrote the paper.

Disclosures

    • Received August 5, 2016.
    • Revision received September 9, 2016.
    • Accepted September 15, 2016.
  • This work was supported by the National Institute on Deafness and Communication Disorders–National Institutes of Health (NIH Grants R01 DC012552, R01 DC014437, and R03 DC011840 to S.S.), the American Federation for Aging Research (Grant 12388 to S.S.), the Claude D. Pepper Older Americans Independence Centers at the University of Florida (NIH National Institute on Aging Grant 1 P30 AG028740), and the Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research 23228003).

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Shinichi Someya, Department of Aging and Geriatric Research, University of Florida, 2004 Mowry Road, P.O. Box 112610, Gainesville, FL 32610. someya{at}ufl.edu

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The Journal of Neuroscience: 36 (44)
Journal of Neuroscience
Vol. 36, Issue 44
2 Nov 2016
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Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice
Chul Han, Dalian Ding, Maria-Cecilia Lopez, Senthilvelan Manohar, Yanping Zhang, Mi-Jung Kim, Hyo-Jin Park, Karessa White, Yong Hwan Kim, Paul Linser, Masaru Tanokura, Christiaan Leeuwenburgh, Henry V. Baker, Richard J. Salvi, Shinichi Someya
Journal of Neuroscience 2 November 2016, 36 (44) 11308-11319; DOI: 10.1523/JNEUROSCI.2493-16.2016

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Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice
Chul Han, Dalian Ding, Maria-Cecilia Lopez, Senthilvelan Manohar, Yanping Zhang, Mi-Jung Kim, Hyo-Jin Park, Karessa White, Yong Hwan Kim, Paul Linser, Masaru Tanokura, Christiaan Leeuwenburgh, Henry V. Baker, Richard J. Salvi, Shinichi Someya
Journal of Neuroscience 2 November 2016, 36 (44) 11308-11319; DOI: 10.1523/JNEUROSCI.2493-16.2016
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Keywords

  • aging
  • exercise
  • hearing loss
  • stria vascularis

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