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Symposium and Mini-Symposium

Frontosubthalamic Circuits for Control of Action and Cognition

Adam R. Aron, Damian M. Herz, Peter Brown, Birte U. Forstmann and Kareem Zaghloul
Journal of Neuroscience 9 November 2016, 36 (45) 11489-11495; DOI: https://doi.org/10.1523/JNEUROSCI.2348-16.2016
Adam R. Aron
1Department of Psychology, University of California San Diego, San Diego, California 92093-0109,
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Damian M. Herz
2Medical Research Council Brain Network Dynamics Unit, and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX1 3TH, United Kingdom,
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Peter Brown
2Medical Research Council Brain Network Dynamics Unit, and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX1 3TH, United Kingdom,
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Birte U. Forstmann
3Amsterdam Brain and Cognition Center, University of Amsterdam, Psychology, Roetersstraat 15, Amsterdam 1018, The Netherlands, and
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Kareem Zaghloul
4National Institute of Neurological Disorders and Stroke, National Institutes of Health, Baltimore, Maryland 20892
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Abstract

The subthalamic nucleus (STN) of the basal ganglia appears to have a potent role in action and cognition. Anatomical and imaging studies show that different frontal cortical areas directly project to the STN via so-called hyperdirect pathways. This review reports some of the latest findings about such circuits, including simultaneous recordings from cortex and the STN in humans, single-unit recordings in humans, high-resolution fMRI, and neurocomputational modeling. We argue that a major function of the STN is to broadly pause behavior and cognition when stop signals, conflict signals, or surprise signals occur, and that the fronto-STN circuits for doing this, at least for stopping and conflict, are dissociable anatomically and in terms of their spectral reactivity. We also highlight recent evidence for synchronization of oscillations between prefrontal cortex and the STN, which may provide a preferential “window in time” for single neuron communication via long-range connections.

  • basal ganglia
  • conflict
  • oscillations
  • response inhibition
  • stopping
  • surprise
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The Journal of Neuroscience: 36 (45)
Journal of Neuroscience
Vol. 36, Issue 45
9 Nov 2016
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Frontosubthalamic Circuits for Control of Action and Cognition
Adam R. Aron, Damian M. Herz, Peter Brown, Birte U. Forstmann, Kareem Zaghloul
Journal of Neuroscience 9 November 2016, 36 (45) 11489-11495; DOI: 10.1523/JNEUROSCI.2348-16.2016

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Frontosubthalamic Circuits for Control of Action and Cognition
Adam R. Aron, Damian M. Herz, Peter Brown, Birte U. Forstmann, Kareem Zaghloul
Journal of Neuroscience 9 November 2016, 36 (45) 11489-11495; DOI: 10.1523/JNEUROSCI.2348-16.2016
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  • Article
    • Abstract
    • Introduction
    • Stopping
    • Conflict
    • Imaging and anatomy
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    • How the STN may impact cognition
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Keywords

  • basal ganglia
  • conflict
  • oscillations
  • response inhibition
  • stopping
  • surprise

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