Figure 1. A, The percentage of correct spontaneous alternations in the T-maze over 5 min, with reduced correct spontaneous alternations observed in FABP5−/− mice, regardless of gender (n = 18 or 19). ***p < 0.001 (two-way ANOVA). B, The time spent in the novel and familiar arm of the Y-maze paradigm over 5 min, with all mice, except female FABP5−/− mice spending significantly more time in the novel arm than familiar arm (n = 16 or 17). ***p < 0.001 (pairwise ANOVA comparison test). C, Performance of FABP5+/+ and FABP5−/− mice (n = 16–18) in the cued training trials and spatial trials in the water maze assessed as absolute escape latency, with FABP5−/− mice showing impaired learning ability for cued training, regardless of gender. ***p < 0.001 (two-way repeated-measures ANOVA). D, In the probe trial of the water maze, FABP5+/+ mice required significantly less time to reach the target zone relative to FABP5−/− mice, regardless of gender (n = 16–18). *p < 0.05 (two-way ANOVA). E, The discrimination index calculated from the novel object recognition, with FABP5−/− mice exhibiting a significantly lower ability to differentiate between the novel object and familiar object, regardless of gender. *p < 0.05 (two-way ANOVA). F, The percentage of contextual freezing reduces significantly in FABP5−/− mice, regardless of gender and retention interval (n = 18–20). ***p < 0.001 (two-way ANOVA). G, A more robust reduction in the percentage of contextual freezing time was observed in FABP5−/− mice in the 4 h reexposure cohort than the 24 h reexposure cohort, regardless of gender.