Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
    • Special Collections
  • EDITORIAL BOARD
    • Editorial Board
    • ECR Advisory Board
    • Journal Staff
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
    • Accessibility
  • SUBSCRIBE
PreviousNext
Cover ArticleBrief Communications

Aβ-Induced Synaptic Alterations Require the E3 Ubiquitin Ligase Nedd4-1

Elizabeth M. Rodrigues, Samantha L. Scudder, Marisa S. Goo and Gentry N. Patrick
Journal of Neuroscience 3 February 2016, 36 (5) 1590-1595; https://doi.org/10.1523/JNEUROSCI.2964-15.2016
Elizabeth M. Rodrigues
University of California San Diego, Section of Neurobiology, Division of Biological Sciences, La Jolla, California 92093-0347
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Samantha L. Scudder
University of California San Diego, Section of Neurobiology, Division of Biological Sciences, La Jolla, California 92093-0347
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marisa S. Goo
University of California San Diego, Section of Neurobiology, Division of Biological Sciences, La Jolla, California 92093-0347
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gentry N. Patrick
University of California San Diego, Section of Neurobiology, Division of Biological Sciences, La Jolla, California 92093-0347
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2964-15.2016
PubMed 
26843640
Published By 
Society for Neuroscience
History 
  • Received August 5, 2015
  • Revision received November 23, 2015
  • Accepted December 15, 2015
  • First published February 3, 2016.
  • Version of record published February 3, 2016.
Copyright & Usage 
Copyright © 2016 the authors 0270-6474/16/361590-06$15.00/0

Author Information

  1. Elizabeth M. Rodrigues,
  2. Samantha L. Scudder,
  3. Marisa S. Goo, and
  4. Gentry N. Patrick
  1. University of California San Diego, Section of Neurobiology, Division of Biological Sciences, La Jolla, California 92093-0347
View Full Text

Author contributions

  1. Author contributions: E.M.R., S.L.S., M.S.G., and G.N.P. designed research; E.M.R., S.L.S., and M.S.G. performed research; E.M.R., S.L.S., M.S.G., and G.N.P. analyzed data; E.M.R., S.L.S., M.S.G., and G.N.P. wrote the paper.

Disclosures

    • Received August 5, 2015.
    • Revision received November 23, 2015.
    • Accepted December 15, 2015.
  • This work was supported by National Institutes of Health Neural Circuits Postdoctoral Training Grant T32 NS007220 to E.M.R., National Science Foundation Graduate Research Fellowships to S.L.S. and M.S.G., National Institutes of Health Grant NS060847 to G.N.P., National Institutes of Health Training Grant T32 AG00216 to S.L.S., and Center for Systems Biology Grant P50-GMO85764. We thank Edward Koo and Floyd Sarsoza (University of California–San Diego) for 7PA2 cells and assistance with ELISA measurements; Stuart Lipton and Mohd Waseem Akhtar (Sanford Burnham) for helpful discussions and reagents; Adrian Lozada and Darwin Berg (University of California–San Diego) for TdTomato lentivirus; members of the G.N.P. laboratory for helpful discussion; and Lara Dozier for technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Gentry N. Patrick, Section of Neurobiology, Division of Biological Sciences, 9500 Gilman Drive, La Jolla, CA 92093-0347. gpatrick{at}ucsd.edu

Online Impact

 

Article usage

Select a custom date range for the past year
E.g., 2025-12-05
to
E.g., 2025-12-05

Article usage: January 2018 to December 2025

AbstractFullPdf
Jan 2018452510
Feb 201832329
Mar 2018112815
Apr 201814257
May 2018124520
Jun 2018173613
Jul 2018163313
Aug 20187145
Sep 201812986
Oct 20181315911
Nov 201817397
Dec 201815136
Total 2018211547122
Jan 201992711
Feb 201914295
Mar 201916568
Apr 2019444210
May 2019283512
Jun 201992412
Jul 2019999
Aug 201913176
Oct 201911217
Nov 2019212316
Dec 20197167
Total 2019181299103
Jan 20202358
Feb 202051713
Mar 20206168
May 202042912
Jun 202033114
Jul 20206296
Aug 202041113
Sep 20204156
Oct 20205577
Nov 202033820
Dec 202052511
Total 202047303118
Jan 202172815
Feb 20214158
Mar 202182220
Apr 202134611
May 20214379
Jun 20211658
Jul 202111214
Aug 20216287
Sep 202111819
Oct 202153426
Nov 202192520
Dec 20211265
Total 202150356162
Jan 202222520
Feb 202223116
Mar 20221164
Apr 20225629
May 202221612
Jun 202222510
Jul 202271712
Aug 20222159
Sep 202201312
Oct 20223168
Nov 2022047
Dec 2022386
Total 202229248125
Jan 202352210
Feb 20236218
Mar 202331712
Apr 20232186
May 202321917
Jun 20231165
Jul 20233178
Aug 20233811
Sep 20233524
Oct 202354713
Nov 202367712
Dec 202324615
Total 202341360121
Jan 20243453
Feb 20243389
Mar 202463012
Apr 202432410
May 20249597
Jun 20245247
Jul 202442610
Aug 202421811
Sep 20242125
Oct 202431412
Nov 20242194
Dec 20240319
Total 20244234099
Jan 202522111
Feb 202504519
Mar 202564224
Apr 202521514
May 20252202
Jun 20251196
Jul 202503119
Aug 202512321
Sep 202512817
Oct 202583310
Nov 202545013
Dec 2025261
Total 202529333157
Total63027861007
Back to top

In this issue

The Journal of Neuroscience: 36 (5)
Journal of Neuroscience
Vol. 36, Issue 5
3 Feb 2016
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Advertising (PDF)
  • Ed Board (PDF)
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Aβ-Induced Synaptic Alterations Require the E3 Ubiquitin Ligase Nedd4-1
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
View Full Page PDF
Citation Tools
Aβ-Induced Synaptic Alterations Require the E3 Ubiquitin Ligase Nedd4-1
Elizabeth M. Rodrigues, Samantha L. Scudder, Marisa S. Goo, Gentry N. Patrick
Journal of Neuroscience 3 February 2016, 36 (5) 1590-1595; DOI: 10.1523/JNEUROSCI.2964-15.2016

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Aβ-Induced Synaptic Alterations Require the E3 Ubiquitin Ligase Nedd4-1
Elizabeth M. Rodrigues, Samantha L. Scudder, Marisa S. Goo, Gentry N. Patrick
Journal of Neuroscience 3 February 2016, 36 (5) 1590-1595; DOI: 10.1523/JNEUROSCI.2964-15.2016
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Keywords

  • Abeta
  • AMPA receptor
  • endocytosis
  • Nedd4-1
  • ubiquitin

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

  • Heteromodal Cortical Areas Encode Sensory-Motor Features of Word Meaning
  • Pharmacologically Counteracting a Phenotypic Difference in Cerebellar GABAA Receptor Response to Alcohol Prevents Excessive Alcohol Consumption in a High Alcohol-Consuming Rodent Genotype
  • Neuromuscular NMDA Receptors Modulate Developmental Synapse Elimination
Show more Brief Communications
  • Home
  • Alerts
  • Follow SFN on BlueSky
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Notice
  • Contact
  • Accessibility
(JNeurosci logo)
(SfN logo)

Copyright © 2025 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.