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Brief Communications

Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice

Leslie M. Tong, Seo Yeon Yoon, Yaisa Andrews-Zwilling, Alyssa Yang, Victoria Lin, Hanci Lei and Yadong Huang
Journal of Neuroscience 17 February 2016, 36 (7) 2316-2322; https://doi.org/10.1523/JNEUROSCI.3815-15.2016
Leslie M. Tong
1Gladstone Institute of Neurological Disease, San Francisco, California 94158, and
2Biomedical Sciences Graduate Program, and
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Seo Yeon Yoon
1Gladstone Institute of Neurological Disease, San Francisco, California 94158, and
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Yaisa Andrews-Zwilling
1Gladstone Institute of Neurological Disease, San Francisco, California 94158, and
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Alyssa Yang
1Gladstone Institute of Neurological Disease, San Francisco, California 94158, and
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Victoria Lin
1Gladstone Institute of Neurological Disease, San Francisco, California 94158, and
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Hanci Lei
1Gladstone Institute of Neurological Disease, San Francisco, California 94158, and
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Yadong Huang
1Gladstone Institute of Neurological Disease, San Francisco, California 94158, and
2Biomedical Sciences Graduate Program, and
3Departments of Neurology and
4Pathology, University of California, San Francisco, California 94143
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The Journal of Neuroscience: 36 (7)
Journal of Neuroscience
Vol. 36, Issue 7
17 Feb 2016
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Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice
Leslie M. Tong, Seo Yeon Yoon, Yaisa Andrews-Zwilling, Alyssa Yang, Victoria Lin, Hanci Lei, Yadong Huang
Journal of Neuroscience 17 February 2016, 36 (7) 2316-2322; DOI: 10.1523/JNEUROSCI.3815-15.2016

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Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice
Leslie M. Tong, Seo Yeon Yoon, Yaisa Andrews-Zwilling, Alyssa Yang, Victoria Lin, Hanci Lei, Yadong Huang
Journal of Neuroscience 17 February 2016, 36 (7) 2316-2322; DOI: 10.1523/JNEUROSCI.3815-15.2016
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Keywords

  • Alzheimer's disease
  • ApoE
  • inhibitory neuron
  • learning and memory
  • middle adulthood
  • pentobarbital

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