Article Information
- Received May 6, 2015
- Revision received December 22, 2015
- Accepted January 29, 2016
- First published March 2, 2016.
- Version of record published March 2, 2016.
Author Information
- Kanehiro Fujiyoshi1,2,6,*,
- Keigo Hikishima2,7,*,
- Jin Nakahara3,*,
- Osahiko Tsuji1,2,
- Junichi Hata2,8,
- Tsunehiko Konomi1,2,6,
- Toshihiro Nagai5,
- Shinsuke Shibata2,
- Shinjiro Kaneko6,
- Akio Iwanami1,
- Suketaka Momoshima4,
- Shinichi Takahashi3,
- Masahiro Jinzaki4,
- Norihiro Suzuki3,
- Yoshiaki Toyama1,
- Masaya Nakamura1, and
- Hideyuki Okano2,8
- 1Departments of Orthopedic Surgery,
- 2Physiology,
- 3Neurology, and
- 4Radiology, and
- 5Electron Microscopic Laboratory, Keio University School of Medicine, Tokyo 160-8582, Japan,
- 6Department of Orthopedic Surgery, National Hospital Organization Murayama Medical Center, Tokyo 208-0011, Japan,
- 7Central Institute for Experimental Animals, Kanagawa 210-0821, Japan, and
- 8Laboratory for Marmoset Neural Architecture, RIKEN Brain Science Institute, Saitama 351-0198, Japan
Author contributions
Author contributions: M.N. and H.O. designed research; K.F., K.H., J.N., O.T., J.H., T.K., T.N., S.S., S.K., A.I., S.M., S.T., M.J., N.S., Y.T., M.N., and H.O. performed research; K.F., K.H., J.N., O.T., J.H., T.K., T.N., S.S., S.K., A.I., S.M., S.T., M.J., N.S., Y.T., M.N. and H.O. analyzed data; K.F., K.H., J.N., O.T., J.H., T.K., T.N., S.S., S.K., A.I., S.M., S.T., M.J., N.S., Y.T., M.N. and H.O. wrote the paper.
↵*K.F., K.H, and J.N. made equal contributions to this work.
Disclosures
- Received May 6, 2015.
- Revision received December 22, 2015.
- Accepted January 29, 2016.
This study was supported by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and the Japan Agency for Medical Research and Development (AMED), including the Strategic Research Program for Brain Sciences, Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS; H.O., J.H., and S.S.), the Research Center Network for Realization of Regenerative Medicine (H.O.), and a Grant-in-Aid for Scientific Research (J.N.); the CREST program from the Japan Science and Technology Agency (M.N.); and by the General Insurance Association of Japan (Y.T. and M.N.). We thank Hiroko Baba for providing the shiverer mutant mice, Kazuhiro Ikenaka and Kenji Tanaka for providing the jimpy mutant mice, Hiroyuki Kato and Seiji Okada for editing and proofreading the manuscript, and Kaori Yasutake for her expertise in animal experiments.
J.N. received honoraria from Novartis Pharma, Bayer Pharmaceutical Japan, Mitsubishi Tanabe Pharma, and Takeda Pharmaceutical and serves as a paid scientific advisor to Novartis Pharma, Bayer Pharmaceutical Japan, Takeda Pharmaceutical, and Biogen Japan. H.O. serves as a paid scientific advisor to SanBio Co. Ltd. The remaining authors declare no competing financial interests.
- Correspondence should be addressed to either Dr. Masaya Nakamura (Department of Orthopedic Surgery) or Dr. Hideyuki Okano (Department of Physiology), Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan. masa{at}a8.keio.jp or hidokano{at}a2.keio.jp
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