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Research Articles, Behavioral/Cognitive

Sex Differences in Microglia Activity within the Periaqueductal Gray of the Rat: A Potential Mechanism Driving the Dimorphic Effects of Morphine

Hillary H. Doyle, Lori N. Eidson, David M. Sinkiewicz and Anne Z. Murphy
Journal of Neuroscience 22 March 2017, 37 (12) 3202-3214; https://doi.org/10.1523/JNEUROSCI.2906-16.2017
Hillary H. Doyle
Neuroscience Institute, Georgia State University, Atlanta, Georgia 30303
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Lori N. Eidson
Neuroscience Institute, Georgia State University, Atlanta, Georgia 30303
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David M. Sinkiewicz
Neuroscience Institute, Georgia State University, Atlanta, Georgia 30303
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Anne Z. Murphy
Neuroscience Institute, Georgia State University, Atlanta, Georgia 30303
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2906-16.2017
PubMed 
28219988
Published By 
Society for Neuroscience
History 
  • Received September 15, 2016
  • Revision received January 30, 2017
  • Accepted February 6, 2017
  • First published February 20, 2017.
  • Version of record published March 22, 2017.
Copyright & Usage 
Copyright © 2017 the authors 0270-6474/17/373202-13$15.00/0

Author Information

  1. Hillary H. Doyle,
  2. Lori N. Eidson,
  3. David M. Sinkiewicz, and
  4. Anne Z. Murphy
  1. Neuroscience Institute, Georgia State University, Atlanta, Georgia 30303
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Author contributions

  1. Author contributions: H.H.D., L.N.E., D.M.S., and A.Z.M. designed research; H.H.D., L.N.E., D.M.S., and A.Z.M. performed research; H.H.D. and A.Z.M. analyzed data; H.H.D. and A.Z.M. wrote the paper.

Disclosures

    • Received September 15, 2016.
    • Revision received January 30, 2017.
    • Accepted February 6, 2017.
  • This work was supported by the National Institutes of Health (Grant DA16272 to A.Z.M.) (−)-Morphine sulfate and (+)-naloxone were kindly provided by the National Institute on Drug Abuse drug supply program. We thank Lauren Hanus and Alyssa Bartlett for technical assistance.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Anne Z. Murphy, Neuroscience Institute, Georgia State University, 100 Piedmont Ave, SE, Atlanta, GA 30303. amurphy{at}gsu.edu

Other Version

  • previous version (February 20, 2017).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 37 (12)
Journal of Neuroscience
Vol. 37, Issue 12
22 Mar 2017
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Sex Differences in Microglia Activity within the Periaqueductal Gray of the Rat: A Potential Mechanism Driving the Dimorphic Effects of Morphine
Hillary H. Doyle, Lori N. Eidson, David M. Sinkiewicz, Anne Z. Murphy
Journal of Neuroscience 22 March 2017, 37 (12) 3202-3214; DOI: 10.1523/JNEUROSCI.2906-16.2017

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Sex Differences in Microglia Activity within the Periaqueductal Gray of the Rat: A Potential Mechanism Driving the Dimorphic Effects of Morphine
Hillary H. Doyle, Lori N. Eidson, David M. Sinkiewicz, Anne Z. Murphy
Journal of Neuroscience 22 March 2017, 37 (12) 3202-3214; DOI: 10.1523/JNEUROSCI.2906-16.2017
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Keywords

  • analgesia
  • microglia
  • morphine
  • nociception
  • pain
  • sex differences

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