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Research Articles, Cellular/Molecular

Wild-Type Monomeric α-Synuclein Can Impair Vesicle Endocytosis and Synaptic Fidelity via Tubulin Polymerization at the Calyx of Held

Kohgaku Eguchi, Zacharie Taoufiq, Oliver Thorn-Seshold, Dirk Trauner, Masato Hasegawa and Tomoyuki Takahashi
Journal of Neuroscience 21 June 2017, 37 (25) 6043-6052; DOI: https://doi.org/10.1523/JNEUROSCI.0179-17.2017
Kohgaku Eguchi
1Cellular and Molecular Synaptic Function Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan,
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  • ORCID record for Kohgaku Eguchi
Zacharie Taoufiq
1Cellular and Molecular Synaptic Function Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan,
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Oliver Thorn-Seshold
2Department of Chemistry and Pharmacy and Centre for Integrated Protein Science, Ludwig-Maximilians-University Munich, 81377 Munich, Germany, and
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Dirk Trauner
2Department of Chemistry and Pharmacy and Centre for Integrated Protein Science, Ludwig-Maximilians-University Munich, 81377 Munich, Germany, and
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Masato Hasegawa
3Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan
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Tomoyuki Takahashi
1Cellular and Molecular Synaptic Function Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.0179-17.2017
PubMed 
28576942
Published By 
Society for Neuroscience
History 
  • Received January 19, 2017
  • Revision received May 8, 2017
  • Accepted May 13, 2017
  • First published June 2, 2017.
  • Version of record published June 21, 2017.
Copyright & Usage 
Copyright © 2017 the authors 0270-6474/17/376043-10$15.00/0

Author Information

  1. Kohgaku Eguchi1,
  2. Zacharie Taoufiq1,
  3. Oliver Thorn-Seshold2,
  4. Dirk Trauner2,
  5. Masato Hasegawa3, and
  6. Tomoyuki Takahashi1
  1. 1Cellular and Molecular Synaptic Function Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan,
  2. 2Department of Chemistry and Pharmacy and Centre for Integrated Protein Science, Ludwig-Maximilians-University Munich, 81377 Munich, Germany, and
  3. 3Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan
  • D. Trauner's present address: Department of Chemistry, New York University, New York, NY 10003.

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Author contributions

  1. Author contributions: K.E. and T.T. designed research; K.E. and Z.T. performed research; O.T.-S., D.T., and M.H. contributed reagents/analytic tools; K.E. and Z.T. analyzed data; K.E. and T.T. wrote the paper.

  • D. Trauner's present address: Department of Chemistry, New York University, New York, NY 10003.

Disclosures

    • Received January 19, 2017.
    • Revision received May 8, 2017.
    • Accepted May 13, 2017.
  • This work was supported by the Okinawa Institute of Science and Technology, the Core Research for Evolutionary Science and Technology of the Japan Science and Technology Agency (T.T.), and the Japan Society for the Promotion of Science (Grant-in-Aid for Young Scientists to K.E.). We thank Yasuo Ihara and Takeshi Sakaba for comments and Steven Aird for editing this manuscript.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to either of the following: Kohgaku Eguchi, Molecular Neuroscience Group, Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria, kohgaku.eguchi{at}ist.ac.at; or Tomoyuki Takahashi, Cellular and Molecular Synaptic Function Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan, ttakahas{at}oist.jp

Other Version

  • previous version (June 02, 2017).
  • You are viewing the most recent version of this article.

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The Journal of Neuroscience: 37 (25)
Journal of Neuroscience
Vol. 37, Issue 25
21 Jun 2017
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Wild-Type Monomeric α-Synuclein Can Impair Vesicle Endocytosis and Synaptic Fidelity via Tubulin Polymerization at the Calyx of Held
Kohgaku Eguchi, Zacharie Taoufiq, Oliver Thorn-Seshold, Dirk Trauner, Masato Hasegawa, Tomoyuki Takahashi
Journal of Neuroscience 21 June 2017, 37 (25) 6043-6052; DOI: 10.1523/JNEUROSCI.0179-17.2017

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Wild-Type Monomeric α-Synuclein Can Impair Vesicle Endocytosis and Synaptic Fidelity via Tubulin Polymerization at the Calyx of Held
Kohgaku Eguchi, Zacharie Taoufiq, Oliver Thorn-Seshold, Dirk Trauner, Masato Hasegawa, Tomoyuki Takahashi
Journal of Neuroscience 21 June 2017, 37 (25) 6043-6052; DOI: 10.1523/JNEUROSCI.0179-17.2017
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Keywords

  • alpha-synuclein
  • calyx of Held
  • microtubules
  • synaptic transmission
  • vesicle endocytosis

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