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Research Articles, Neurobiology of Disease

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

Taylor R. Jay, Anna M. Hirsch, Margaret L. Broihier, Crystal M. Miller, Lee E. Neilson, Richard M. Ransohoff, Bruce T. Lamb and Gary E. Landreth
Journal of Neuroscience 18 January 2017, 37 (3) 637-647; DOI: https://doi.org/10.1523/JNEUROSCI.2110-16.2016
Taylor R. Jay
1Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106,
2Department of Neurosciences, The Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195,
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Anna M. Hirsch
1Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106,
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Margaret L. Broihier
1Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106,
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Crystal M. Miller
2Department of Neurosciences, The Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195,
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Lee E. Neilson
1Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106,
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Richard M. Ransohoff
3Neuroimmunology/Discovery Biology, Biogen, Cambridge, Massachusetts 02142, and
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Bruce T. Lamb
1Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106,
4Stark Neurosciences Research Institute, Indiana University, Indianapolis, Indiana 46202
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Gary E. Landreth
1Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2110-16.2016
PubMed 
28100745
Published By 
Society for Neuroscience
History 
  • Received June 30, 2016
  • Revision received November 30, 2016
  • Accepted December 5, 2016
  • First published December 9, 2016.
  • Version of record published January 18, 2017.
Copyright & Usage 
Copyright © 2017 the authors 0270-6474/17/370637-11$15.00/0

Author Information

  1. Taylor R. Jay1,2,
  2. Anna M. Hirsch1,
  3. Margaret L. Broihier1,
  4. Crystal M. Miller2,
  5. Lee E. Neilson1,
  6. Richard M. Ransohoff3,
  7. Bruce T. Lamb1,4, and
  8. Gary E. Landreth1
  1. 1Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106,
  2. 2Department of Neurosciences, The Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195,
  3. 3Neuroimmunology/Discovery Biology, Biogen, Cambridge, Massachusetts 02142, and
  4. 4Stark Neurosciences Research Institute, Indiana University, Indianapolis, Indiana 46202
View Full Text

Author contributions

  1. Author contributions: T.R.J., A.M.H., M.L.B., B.T.L., and G.E.L. designed research; T.R.J., A.M.H., M.L.B., and C.M.M. performed research; R.M.R. contributed unpublished reagents/analytic tools; T.R.J., A.M.H., M.L.B., and L.E.N. analyzed data; T.R.J. wrote the paper.

View Abstract

Disclosures

    • Received June 30, 2016.
    • Revision received November 30, 2016.
    • Accepted December 5, 2016.
  • This work was supported by the Alzheimer's Association (Grant BFG-15–364590 to G.E.L.), the Jane and Lee Seidman Fund, generous donations from Chet and Jane Scholtz and Dave and Susan Roberts (B.T.L.), the National Institute on Aging–National Institutes of Health (NIA Grant RF1 AG051495 to B.T.L. and G.E.L.; NIA Grant R01 AG050597 to G.E.L.; and NIA National Research Service Award F31 AG048704 to T.R.J.), and Case Western Reserve University (Neurosciences Training Grant T32 NS067431 to T.R.J.). We thank the imaging core at Case Western Reserve University and the flow cytometry core at the Cleveland Clinic Lerner Research Institute for technical support.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Gary E. Landreth, Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106. gel2{at}case.edu

Other Version

  • previous version (December 09, 2016).
  • You are viewing the most recent version of this article.

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Apr 201744015889
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The Journal of Neuroscience: 37 (3)
Journal of Neuroscience
Vol. 37, Issue 3
18 Jan 2017
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Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease
Taylor R. Jay, Anna M. Hirsch, Margaret L. Broihier, Crystal M. Miller, Lee E. Neilson, Richard M. Ransohoff, Bruce T. Lamb, Gary E. Landreth
Journal of Neuroscience 18 January 2017, 37 (3) 637-647; DOI: 10.1523/JNEUROSCI.2110-16.2016

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Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease
Taylor R. Jay, Anna M. Hirsch, Margaret L. Broihier, Crystal M. Miller, Lee E. Neilson, Richard M. Ransohoff, Bruce T. Lamb, Gary E. Landreth
Journal of Neuroscience 18 January 2017, 37 (3) 637-647; DOI: 10.1523/JNEUROSCI.2110-16.2016
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Keywords

  • AD
  • genetic risk factor
  • inflammation
  • microglia
  • myeloid cell
  • neuroinflammation

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