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Research Articles, Development/Plasticity/Repair

Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination

Lauren E. McLane, Jennifer N. Bourne, Angelina V. Evangelou, Luipa Khandker, Wendy B. Macklin and Teresa L. Wood
Journal of Neuroscience 2 August 2017, 37 (31) 7534-7546; DOI: https://doi.org/10.1523/JNEUROSCI.3454-16.2017
Lauren E. McLane
1Department of Pharmacology, Physiology, and Neuroscience and Cancer Center, New Jersey Medical School, Rutgers University, Newark, New Jersey 07101, and
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  • ORCID record for Lauren E. McLane
Jennifer N. Bourne
2Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045
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Angelina V. Evangelou
1Department of Pharmacology, Physiology, and Neuroscience and Cancer Center, New Jersey Medical School, Rutgers University, Newark, New Jersey 07101, and
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Luipa Khandker
1Department of Pharmacology, Physiology, and Neuroscience and Cancer Center, New Jersey Medical School, Rutgers University, Newark, New Jersey 07101, and
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Wendy B. Macklin
2Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045
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Teresa L. Wood
1Department of Pharmacology, Physiology, and Neuroscience and Cancer Center, New Jersey Medical School, Rutgers University, Newark, New Jersey 07101, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.3454-16.2017
PubMed 
28694334
Published By 
Society for Neuroscience
History 
  • Received November 3, 2016
  • Revision received June 9, 2017
  • Accepted June 17, 2017
  • First published July 10, 2017.
  • Version of record published August 2, 2017.
Copyright & Usage 
Copyright © 2017 the authors 0270-6474/17/377534-13$15.00/0

Author Information

  1. Lauren E. McLane1,
  2. Jennifer N. Bourne2,
  3. Angelina V. Evangelou1,
  4. Luipa Khandker1,
  5. Wendy B. Macklin2, and
  6. Teresa L. Wood1
  1. 1Department of Pharmacology, Physiology, and Neuroscience and Cancer Center, New Jersey Medical School, Rutgers University, Newark, New Jersey 07101, and
  2. 2Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 80045
View Full Text

Author contributions

  1. Author contributions: L.E.M. and T.L.W. designed research; L.E.M., J.N.B., A.V.E., and L.K. performed research; W.B.M. contributed unpublished reagents/analytic tools; L.E.M. and T.L.W. analyzed data; L.E.M. and T.L.W. wrote the paper.

Disclosures

    • Received November 3, 2016.
    • Revision received June 9, 2017.
    • Accepted June 17, 2017.
  • This work was supported by National Institute of Neurological Disorders and Stroke–National Institutes of Health (Grant NS082203 to W.B.M. and T.L.W.), the National Multiple Sclerosis Society (Grant RG5371-A-4), and the Department of Defense Tuberous Sclerosis Complex Research Program (Exploration Award TS093091 to T.L.W.). We thank Quan Shang and Danielle Harlow for technical assistance, Sharyl Fyffe-Maricich for helpful discussions, and Amy Davidow for statistical consultation and analysis.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Teresa L. Wood, Ph.D., Department Pharmacology, Physiology, and Neuroscience, New Jersey Medical School Cancer Center H1200, Rutgers University, 205 S. Orange Ave, Newark, NJ 07101-1709. Terri.wood{at}rutgers.edu

Other Version

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Jul 201710530117
Aug 20171625257144
Sep 20171954938
Oct 20171475735
Nov 20172624823
Dec 20171581816
Total 20173440429373
Jan 2018872814
Feb 2018493120
Mar 2018163022
Apr 2018123123
May 2018134630
Jun 2018144528
Jul 2018203111
Aug 2018232516
Sep 2018162214
Oct 201811279
Nov 2018193618
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Total 2018290371215
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Apr 2019153119
May 201972423
Jun 20197235
Jul 201931811
Aug 2019112515
Sep 201961712
Oct 201992810
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Dec 201952010
Total 201998277170
Jan 202022114
Feb 202072714
Mar 202072114
Apr 202052732
May 202052825
Jun 202061823
Jul 202033329
Aug 20202166
Sep 202063230
Oct 20206338
Nov 202043112
Dec 20201299
Total 202054316216
Jan 202192810
Feb 202163816
Mar 202143115
Apr 20211167
Total 20212011348
Total390215061022
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The Journal of Neuroscience: 37 (31)
Journal of Neuroscience
Vol. 37, Issue 31
2 Aug 2017
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Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination
Lauren E. McLane, Jennifer N. Bourne, Angelina V. Evangelou, Luipa Khandker, Wendy B. Macklin, Teresa L. Wood
Journal of Neuroscience 2 August 2017, 37 (31) 7534-7546; DOI: 10.1523/JNEUROSCI.3454-16.2017

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Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination
Lauren E. McLane, Jennifer N. Bourne, Angelina V. Evangelou, Luipa Khandker, Wendy B. Macklin, Teresa L. Wood
Journal of Neuroscience 2 August 2017, 37 (31) 7534-7546; DOI: 10.1523/JNEUROSCI.3454-16.2017
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Keywords

  • adult OPCs
  • mTOR
  • NG2
  • remyelination
  • TSC

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