Article Information
- Received January 2, 2017
- Revision received June 15, 2017
- Accepted June 24, 2017
- First published July 19, 2017.
- Version of record published August 16, 2017.
Author Information
- Natascha Schaefer1,*,
- Alexandra Berger2,*,
- Johannes van Brederode3,
- Fang Zheng3,
- Yan Zhang5,
- Sophie Leacock6,
- Laura Littau1,
- Sibylle Jablonka1,
- Sony Malhotra7,
- Maya Topf8,
- Friederike Winter4,
- Daria Davydova1,
- Joseph W. Lynch5,
- Christopher J. Paige2,
- Christian Alzheimer3,
- Robert J. Harvey6, and
- Carmen Villmann1
- 1Institute of Clinical Neurobiology, Julius-Maximilians-University of Würzburg, 97078 Würzburg, Germany,
- 2Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario M5G 2M9, Canada,
- 3Institute of Physiology and Pathophysiology, and
- 4Institute of Biochemistry, Friedrich-Alexander-University Erlangen-Nürnberg, 91054 Erlangen-Nürnberg, Germany,
- 5Queensland Brain Institute, University of Queensland, Brisbane 4072, Australia,
- 6Department of Pharmacology, UCL School of Pharmacy, London WC1N 1AX, United Kingdom,
- 7Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom, and
- 8Institute of Structural and Molecular Biology, UCL Birkbeck College, London WC1E 7HX, United Kingdom
Author contributions
Author contributions: J.W.L., C.J.P., C.A., R.J.H., and C.V. designed research; N.S., A.B., J.v.B., F.Z., Y.Z., S.L., L.L., S.J., S.M., M.T., F.W., D.D., and C.V. performed research; D.D., J.W.L., C.J.P., C.A., and R.J.H. contributed unpublished reagents/analytic tools; N.S., A.B., J.v.B., F.Z., Y.Z., S.L., L.L., S.J., S.M., M.T., F.W., D.D., R.J.H., and C.V. analyzed data; C.V. wrote the paper.
↵*N.S and A.B. contributed equally to this work
Disclosures
- Received January 2, 2017.
- Revision received June 15, 2017.
- Accepted June 24, 2017.
This work was supported by Deutsche Forschungsgemeinschaft Grant VI586 (C.V.); the Terry Fox Foundation and the Canadian Institutes for Health Research (C.J.P.); and the MRC (Grant MR/J004049/1 to R.J.H. and Grant MR/M019292/1 to M.T.). N.S. was supported by the GSLS Würzburg. We thank Professors K. Schiebel and M. Sendtner for critical reading of the manuscript and helpful comments. We also thank Professor C.-M. Becker for providing mutant mouse lines. In addition, we thank Nadine Vornberger and Gudrun Schell for excellent technical assistance.
The authors declare no competing financial interests.
- Correspondence should be addressed to Dr. Carmen Villmann, Institute of Clinical Neurobiology, University of Wuerzburg, Versbacherstrasse 5, D-97078 Würzburg, Germany. villmann_c{at}ukw.de
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