This image shows acetylcholine receptors (red) and the presynaptic marker bassoon (green) in a mouse neuromuscular junction. Depressed neuromuscular transmission in a Huntington’s disease (R6/2) mouse may help compensate for muscle hyperexcitability and contribute to motor impersistence. For more information, see the article by Khedraki et al. (pages 8077–8091).