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Featured ArticleResearch Articles, Cellular/Molecular

Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat Reproductive Cycle Regulates Spinal Endomorphin 2 Antinociception: Relevance of Endogenous-Biased Agonism

Nai-Jiang Liu, Vijaya Murugaiyan, Emiliya M. Storman, Stephen A. Schnell, Arjun Kumar, Martin W. Wessendorf and Alan R. Gintzler
Journal of Neuroscience 15 November 2017, 37 (46) 11181-11191; DOI: https://doi.org/10.1523/JNEUROSCI.1927-17.2017
Nai-Jiang Liu
1Department of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, and
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Vijaya Murugaiyan
1Department of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, and
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Emiliya M. Storman
1Department of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, and
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Stephen A. Schnell
2Department of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455
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Arjun Kumar
1Department of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, and
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Martin W. Wessendorf
2Department of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455
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Alan R. Gintzler
1Department of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, and
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1927-17.2017
PubMed 
29025923
Published By 
Society for Neuroscience
History 
  • Received July 6, 2017
  • Revision received September 6, 2017
  • Accepted October 2, 2017
  • First published October 12, 2017.
  • Version of record published November 15, 2017.
Copyright & Usage 
Copyright © 2017 the authors 0270-6474/17/3711181-11$15.00/0

Author Information

  1. Nai-Jiang Liu1,*,
  2. Vijaya Murugaiyan1,*,
  3. Emiliya M. Storman1,*,
  4. Stephen A. Schnell2,
  5. Arjun Kumar1,
  6. Martin W. Wessendorf2, and
  7. Alan R. Gintzler1
  1. 1Department of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, and
  2. 2Department of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455
View Full Text

Author contributions

  1. Author contributions: N.-J.L., V.M., E.M.S., S.A.S., A.K., M.W.W., and A.R.G. designed research; N.-J.L., V.M., E.M.S., S.A.S., A.K., and M.W.W. performed research; N.-J.L., V.M., E.M.S., S.A.S., A.K., M.W.W., and A.R.G. analyzed data; N.-J.L., V.M., E.M.S., A.K., M.W.W., and A.R.G. wrote the paper.

  2. ↵*N.-J.L., V.M., and E.M.S. contributed equally to this work.

View Abstract

Disclosures

    • Received July 6, 2017.
    • Revision received September 6, 2017.
    • Accepted October 2, 2017.
  • This work was supported by National Institute on Drug Abuse Grants DA027663 (N.-J.L. and A.R.G.) and DA043774 (N.-J.L. and A.R.G.) and by the Department of Neuroscience, School of Medicine, University of Minnesota (M.W.W.) and by the University Imaging Centers, University of Minnesota (M.W.W.).

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Alan Gintzler, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203. alan.gintzler{at}downstate.edu

Other Version

  • previous version (October 12, 2017).
  • previous version (October 13, 2017).
  • You are viewing the most recent version of this article.

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Jan 20181532626
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Apr 202152010
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May 202322315
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Total 20234719698
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The Journal of Neuroscience: 37 (46)
Journal of Neuroscience
Vol. 37, Issue 46
15 Nov 2017
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Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat Reproductive Cycle Regulates Spinal Endomorphin 2 Antinociception: Relevance of Endogenous-Biased Agonism
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Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat Reproductive Cycle Regulates Spinal Endomorphin 2 Antinociception: Relevance of Endogenous-Biased Agonism
Nai-Jiang Liu, Vijaya Murugaiyan, Emiliya M. Storman, Stephen A. Schnell, Arjun Kumar, Martin W. Wessendorf, Alan R. Gintzler
Journal of Neuroscience 15 November 2017, 37 (46) 11181-11191; DOI: 10.1523/JNEUROSCI.1927-17.2017

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Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat Reproductive Cycle Regulates Spinal Endomorphin 2 Antinociception: Relevance of Endogenous-Biased Agonism
Nai-Jiang Liu, Vijaya Murugaiyan, Emiliya M. Storman, Stephen A. Schnell, Arjun Kumar, Martin W. Wessendorf, Alan R. Gintzler
Journal of Neuroscience 15 November 2017, 37 (46) 11181-11191; DOI: 10.1523/JNEUROSCI.1927-17.2017
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Keywords

  • antinociception
  • biased agonism
  • dynorphin
  • endomorphin 2
  • estrous cycle
  • κ-opioid receptor

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