This image shows two human astrocytes derived from embryonic stem cells stained with F-actin (green). The astrocytes were exposed to Cy-3 labeled alpha-synuclein oligomers (red) for 24 hours, washed and cultured for additional three days. During the 24 h of exposure, the astrocytes engulf large amounts of oligomeric alpha-synuclein that are subsequently accumulated in the cells. The stressed astrocytes respond by sending out tunneling nanotubes, enabling intercellular transfer of alphasynuclein. For more information, see the article by Rostami et al. (pages 11835–11853).