This picture illustrates the analysis of long-term potentiation (LTP) on thousands of isolated synapses by FASS-LTP (Fluorescence Analysis of Single-Synapse LTP). FASS-LTP is a novel method that tracks the insertion of glutamate receptors (green) directly at synapses, which are aligned and analyzed by flow cytometry. Notably, FASS-LTP data on cryopreserved human brains support the idea that synapses in Alzheimer disease patients are intrinsically defective in LTP. Image courtesy of artist César Gallo (El Gallo Films, Costa Mesa, CA). For more information, see the article by Prieto et al. (pages 1197–1212).