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Cover ArticleFeatured ArticleResearch Articles, Cellular/Molecular

Survival of a Novel Subset of Midbrain Dopaminergic Neurons Projecting to the Lateral Septum Is Dependent on NeuroD Proteins

Shabana Khan, Simon R.W. Stott, Audrey Chabrat, Anna M. Truckenbrodt, Bradley Spencer-Dene, Klaus-Armin Nave, François Guillemot, Martin Levesque and Siew-Lan Ang
Journal of Neuroscience 1 March 2017, 37 (9) 2305-2316; https://doi.org/10.1523/JNEUROSCI.2414-16.2016
Shabana Khan
1Francis Crick Institute, Mill Hill Laboratory, Mill Hill, NW7 1AA, United Kingdom,
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  • ORCID record for Shabana Khan
Simon R.W. Stott
1Francis Crick Institute, Mill Hill Laboratory, Mill Hill, NW7 1AA, United Kingdom,
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Audrey Chabrat
2Department of Psychiatry and Neurosciences, Université Laval, Quebec G1V 0A6, Canada,
3Centre de recherche de l'Institut universitaire en santé mentale de Québec, Quebec G1J 2G3, Canada,
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Anna M. Truckenbrodt
1Francis Crick Institute, Mill Hill Laboratory, Mill Hill, NW7 1AA, United Kingdom,
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  • ORCID record for Anna M. Truckenbrodt
Bradley Spencer-Dene
4Francis Crick Institute, Lincoln's Inn Fields Laboratory, London, WC2A 3LY, United Kingdom, and
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Klaus-Armin Nave
5Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany
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François Guillemot
1Francis Crick Institute, Mill Hill Laboratory, Mill Hill, NW7 1AA, United Kingdom,
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Martin Levesque
2Department of Psychiatry and Neurosciences, Université Laval, Quebec G1V 0A6, Canada,
3Centre de recherche de l'Institut universitaire en santé mentale de Québec, Quebec G1J 2G3, Canada,
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Siew-Lan Ang
1Francis Crick Institute, Mill Hill Laboratory, Mill Hill, NW7 1AA, United Kingdom,
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.2414-16.2016
PubMed 
28130357
Published By 
Society for Neuroscience
History 
  • Received July 29, 2016
  • Revision received November 7, 2016
  • Accepted November 30, 2016
  • First published January 27, 2017.
  • Version of record published March 1, 2017.
Copyright & Usage 
Copyright © 2017 Khan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

Author Information

  1. Shabana Khan1,
  2. Simon R.W. Stott1,
  3. Audrey Chabrat2,3,
  4. Anna M. Truckenbrodt1,
  5. Bradley Spencer-Dene4,
  6. Klaus-Armin Nave5,
  7. François Guillemot1,
  8. Martin Levesque2,3, and
  9. Siew-Lan Ang1
  1. 1Francis Crick Institute, Mill Hill Laboratory, Mill Hill, NW7 1AA, United Kingdom,
  2. 2Department of Psychiatry and Neurosciences, Université Laval, Quebec G1V 0A6, Canada,
  3. 3Centre de recherche de l'Institut universitaire en santé mentale de Québec, Quebec G1J 2G3, Canada,
  4. 4Francis Crick Institute, Lincoln's Inn Fields Laboratory, London, WC2A 3LY, United Kingdom, and
  5. 5Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany
  • A.M. Truckenbrodt's present address: Institute of Developmental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, D-85764 Neuherberg, Germany.

  • S.R.W. Stott's present address: John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, United Kingdom.

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Author contributions

  1. Author contributions: S.K., S.R.W.S., A.C., B.S.-D., M.L., and S.-L.A. designed research; S.K., S.R.W.S., A.C., A.M.T., and B.S.-D. performed research; K.-A.N. contributed unpublished reagents/analytic tools; S.K., S.R.W.S., A.C., A.M.T., K.-A.N., F.G., M.L., and S.-L.A. analyzed data; S.K., F.G., and S.-L.A. wrote the paper.

  • A.M. Truckenbrodt's present address: Institute of Developmental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, D-85764 Neuherberg, Germany.

  • S.R.W. Stott's present address: John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, United Kingdom.

Disclosures

    • Received July 29, 2016.
    • Revision received November 7, 2016.
    • Accepted November 30, 2016.
  • This work was supported by the Francis Crick Institute, which receives its core funding from United Kingdom Medical Research Council and the Wellcome Trust. We thank Mary Green and Alessandro Pristera for thoughtful discussions and input.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Siew-Lan Ang, Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom. siew-lan.ang{at}crick.ac.uk

Other Version

  • previous version (January 27, 2017).
  • You are viewing the most recent version of this article.

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Total 20252716357
Total71831101401
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The Journal of Neuroscience: 37 (9)
Journal of Neuroscience
Vol. 37, Issue 9
1 Mar 2017
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Survival of a Novel Subset of Midbrain Dopaminergic Neurons Projecting to the Lateral Septum Is Dependent on NeuroD Proteins
Shabana Khan, Simon R.W. Stott, Audrey Chabrat, Anna M. Truckenbrodt, Bradley Spencer-Dene, Klaus-Armin Nave, François Guillemot, Martin Levesque, Siew-Lan Ang
Journal of Neuroscience 1 March 2017, 37 (9) 2305-2316; DOI: 10.1523/JNEUROSCI.2414-16.2016

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Survival of a Novel Subset of Midbrain Dopaminergic Neurons Projecting to the Lateral Septum Is Dependent on NeuroD Proteins
Shabana Khan, Simon R.W. Stott, Audrey Chabrat, Anna M. Truckenbrodt, Bradley Spencer-Dene, Klaus-Armin Nave, François Guillemot, Martin Levesque, Siew-Lan Ang
Journal of Neuroscience 1 March 2017, 37 (9) 2305-2316; DOI: 10.1523/JNEUROSCI.2414-16.2016
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Keywords

  • lateral septum
  • midbrain dopaminergic neurons
  • NeuroD1
  • Neurod6
  • neuronal diversity
  • ventral tegmental area

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