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Research Articles, Behavioral/Cognitive

Inactivation of the Prelimbic Cortex Attenuates Context-Dependent Operant Responding

Sydney Trask, Megan L. Shipman, John T. Green and Mark E. Bouton
Journal of Neuroscience 1 March 2017, 37 (9) 2317-2324; https://doi.org/10.1523/JNEUROSCI.3361-16.2017
Sydney Trask
University of Vermont, Burlington, Vermont 05405-0134
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Megan L. Shipman
University of Vermont, Burlington, Vermont 05405-0134
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John T. Green
University of Vermont, Burlington, Vermont 05405-0134
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Mark E. Bouton
University of Vermont, Burlington, Vermont 05405-0134
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    Figure 1.

    Cannulae tip placements in PL cortex as verified on Nissl-stained sections. Modified with permission from Paxinos and Watson (2007). Bottom, Representative image of the bilateral cannulae tracks in the PL cortex. Arrows indicate where B/M or vehicle was infused through internal cannulae, which protruded 1 mm below guide cannulae.

  • Figure 2.
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    Figure 2.

    Results from acquisition (A) and testing (B) in Experiment 1. Error bars indicate SEM. There are changes in y axes. Although groups responded similarly during acquisition, PL inactivation before testing attenuated responding in Context A (where responding had been trained), but not Context B (where responding had not been trained).

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    Figure 3.

    Results from acquisition (A), extinction (B), and renewal testing (C) in Experiment 2a. Error bars indicate SEM. There are changes in y axes. Groups did not differ in acquisition or extinction. PL inactivation before testing had no impact on renewal in a context where responding had not been trained, which was robust and similar between groups.

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    Figure 4.

    Results from acquisition and extinction (A), and renewal testing (B) in Experiment 2b. Error bars indicate SEM. There are changes in y axes. Although groups responded similarly in acquisition and extinction, PL inactivation before testing attenuated renewal in Context A and had no impact in Context B.

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The Journal of Neuroscience: 37 (9)
Journal of Neuroscience
Vol. 37, Issue 9
1 Mar 2017
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Inactivation of the Prelimbic Cortex Attenuates Context-Dependent Operant Responding
Sydney Trask, Megan L. Shipman, John T. Green, Mark E. Bouton
Journal of Neuroscience 1 March 2017, 37 (9) 2317-2324; DOI: 10.1523/JNEUROSCI.3361-16.2017

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Inactivation of the Prelimbic Cortex Attenuates Context-Dependent Operant Responding
Sydney Trask, Megan L. Shipman, John T. Green, Mark E. Bouton
Journal of Neuroscience 1 March 2017, 37 (9) 2317-2324; DOI: 10.1523/JNEUROSCI.3361-16.2017
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Keywords

  • context
  • instrumental learning
  • operant conditioning
  • renewal

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