Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception

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¹Department of Neurosciences,
²Department of Anesthesiology, University of California San Diego, School of Medicine, La Jolla, California 92093,
³Department of Oral Surgery, University of California San Francisco, San Francisco, California 94143,
⁴Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 200025,
⁵Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 143-701, South Korea,
⁶Department of Neurology, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China 150001,
⁷Department of Chemistry,
⁸Department of Neurosciences, Stanford University, Stanford, California 94305,
⁹Department of Biochemistry, Neuroscience Program, Center for Biophysics and Quantitative Biology, Chemistry-Biology Interface Training Program, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, and
¹⁰V.A. San Diego Healthcare System, San Diego, California 92161

Author contributions: K.S., L.F.F., W.Y., X.Z., K.Z., B.C., W.C.M., J.D.L., and C.W. designed research; K.S., L.F.F., W.Y., C.C., X.Z., Y.G., S.L., K.Z., M.L.P., M.T.M., and C.W. performed research; K.S., W.Y., M.L.P., M.T.M., W.C.M., J.D.L., and C.W. analyzed data; K.S., W.C.M., J.D.L., and C.W. wrote the paper.

This work was supported by the National Institutes of Health [Grant PN2 EY016525 and University of California–San Diego (UCSD) Alzheimer's Disease Research Center P50 Pilot Grant to W.C.M.; Grant R01 NS084545 to J.D.L.; and UCSD T32 Neuroplasticity of Aging Training Grant to K.S.], the Down Syndrome Research and Treatment Foundation (W.C.M.), the Larry L. Hillblom Foundation (W.C.M.), the Alzheimer's Association (W.C.M., the Thrasher Research Fund (W.C.M.), and the Larry L. Hillblom Foundation (Tauopathy Foundation startup grant to C.W.). We thank Pauline Hu for assistance in DRG cultures, and R. Shibata and N.D. Storslett for assistance with protein purification.
The authors declare no competing financial interests.
Correspondence should be addressed to Dr. Chengbiao Wu, Department of Neurosciences, University of California San Diego, Medical Teaching Facility, Room 312 MC-0624, 9500 Gilman Drive, La Jolla, CA 92093. chw049{at}ucsd.edu

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