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Research Articles, Cellular/Molecular

Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception

Kijung Sung, Luiz F. Ferrari, Wanlin Yang, ChiHye Chung, Xiaobei Zhao, Yingli Gu, Suzhen Lin, Kai Zhang, Bianxiao Cui, Matthew L. Pearn, Michael T. Maloney, William C. Mobley, Jon D. Levine and Chengbiao Wu
Journal of Neuroscience 4 April 2018, 38 (14) 3394-3413; DOI: https://doi.org/10.1523/JNEUROSCI.1686-17.2018
Kijung Sung
1Department of Neurosciences,
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Luiz F. Ferrari
3Department of Oral Surgery, University of California San Francisco, San Francisco, California 94143,
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Wanlin Yang
1Department of Neurosciences,
4Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 200025,
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ChiHye Chung
5Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 143-701, South Korea,
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Xiaobei Zhao
1Department of Neurosciences,
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Yingli Gu
1Department of Neurosciences,
6Department of Neurology, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China 150001,
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Suzhen Lin
1Department of Neurosciences,
4Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 200025,
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Kai Zhang
7Department of Chemistry,
9Department of Biochemistry, Neuroscience Program, Center for Biophysics and Quantitative Biology, Chemistry-Biology Interface Training Program, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, and
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Bianxiao Cui
7Department of Chemistry,
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Matthew L. Pearn
2Department of Anesthesiology, University of California San Diego, School of Medicine, La Jolla, California 92093,
10V.A. San Diego Healthcare System, San Diego, California 92161
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Michael T. Maloney
8Department of Neurosciences, Stanford University, Stanford, California 94305,
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William C. Mobley
1Department of Neurosciences,
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Jon D. Levine
3Department of Oral Surgery, University of California San Francisco, San Francisco, California 94143,
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Chengbiao Wu
1Department of Neurosciences,
10V.A. San Diego Healthcare System, San Diego, California 92161
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Article Information

DOI 
https://doi.org/10.1523/JNEUROSCI.1686-17.2018
PubMed 
29483280
Published By 
Society for Neuroscience
History 
  • Received May 22, 2017
  • Revision received January 23, 2018
  • Accepted February 12, 2018
  • First published February 26, 2018.
  • Version of record published April 4, 2018.
Copyright & Usage 
Copyright © 2018 the authors 0270-6474/18/383395-20$15.00/0

Author Information

  1. Kijung Sung1,
  2. Luiz F. Ferrari3,
  3. Wanlin Yang1,4,
  4. ChiHye Chung5,
  5. Xiaobei Zhao1,
  6. Yingli Gu1,6,
  7. Suzhen Lin1,4,
  8. Kai Zhang7,9,
  9. Bianxiao Cui7,
  10. Matthew L. Pearn2,10,
  11. Michael T. Maloney8,
  12. William C. Mobley1,
  13. Jon D. Levine3, and
  14. Chengbiao Wu1,10
  1. 1Department of Neurosciences,
  2. 2Department of Anesthesiology, University of California San Diego, School of Medicine, La Jolla, California 92093,
  3. 3Department of Oral Surgery, University of California San Francisco, San Francisco, California 94143,
  4. 4Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 200025,
  5. 5Department of Biological Sciences, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul, 143-701, South Korea,
  6. 6Department of Neurology, the Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, China 150001,
  7. 7Department of Chemistry,
  8. 8Department of Neurosciences, Stanford University, Stanford, California 94305,
  9. 9Department of Biochemistry, Neuroscience Program, Center for Biophysics and Quantitative Biology, Chemistry-Biology Interface Training Program, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, and
  10. 10V.A. San Diego Healthcare System, San Diego, California 92161
View Full Text

Author contributions

  1. Author contributions: K.S., L.F.F., W.Y., X.Z., K.Z., B.C., W.C.M., J.D.L., and C.W. designed research; K.S., L.F.F., W.Y., C.C., X.Z., Y.G., S.L., K.Z., M.L.P., M.T.M., and C.W. performed research; K.S., W.Y., M.L.P., M.T.M., W.C.M., J.D.L., and C.W. analyzed data; K.S., W.C.M., J.D.L., and C.W. wrote the paper.

Disclosures

    • Received May 22, 2017.
    • Revision received January 23, 2018.
    • Accepted February 12, 2018.
  • This work was supported by the National Institutes of Health [Grant PN2 EY016525 and University of California–San Diego (UCSD) Alzheimer's Disease Research Center P50 Pilot Grant to W.C.M.; Grant R01 NS084545 to J.D.L.; and UCSD T32 Neuroplasticity of Aging Training Grant to K.S.], the Down Syndrome Research and Treatment Foundation (W.C.M.), the Larry L. Hillblom Foundation (W.C.M.), the Alzheimer's Association (W.C.M., the Thrasher Research Fund (W.C.M.), and the Larry L. Hillblom Foundation (Tauopathy Foundation startup grant to C.W.). We thank Pauline Hu for assistance in DRG cultures, and R. Shibata and N.D. Storslett for assistance with protein purification.

  • The authors declare no competing financial interests.

  • Correspondence should be addressed to Dr. Chengbiao Wu, Department of Neurosciences, University of California San Diego, Medical Teaching Facility, Room 312 MC-0624, 9500 Gilman Drive, La Jolla, CA 92093. chw049{at}ucsd.edu

Other Version

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The Journal of Neuroscience: 38 (14)
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Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception
Kijung Sung, Luiz F. Ferrari, Wanlin Yang, ChiHye Chung, Xiaobei Zhao, Yingli Gu, Suzhen Lin, Kai Zhang, Bianxiao Cui, Matthew L. Pearn, Michael T. Maloney, William C. Mobley, Jon D. Levine, Chengbiao Wu
Journal of Neuroscience 4 April 2018, 38 (14) 3394-3413; DOI: 10.1523/JNEUROSCI.1686-17.2018

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Swedish Nerve Growth Factor Mutation (NGFR100W) Defines a Role for TrkA and p75NTR in Nociception
Kijung Sung, Luiz F. Ferrari, Wanlin Yang, ChiHye Chung, Xiaobei Zhao, Yingli Gu, Suzhen Lin, Kai Zhang, Bianxiao Cui, Matthew L. Pearn, Michael T. Maloney, William C. Mobley, Jon D. Levine, Chengbiao Wu
Journal of Neuroscience 4 April 2018, 38 (14) 3394-3413; DOI: 10.1523/JNEUROSCI.1686-17.2018
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Keywords

  • NGF
  • nociception
  • P75
  • sensory neuron
  • TrkA
  • trophic

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