Article Information
- Received August 22, 2017
- Revision received March 8, 2018
- Accepted March 14, 2018
- First published April 2, 2018.
- Version of record published April 25, 2018.
Author Information
- Eugene Mironets1,
- Patrick Osei-Owusu2,
- Valerie Bracchi-Ricard3,
- Roman Fischer3,
- Elizabeth A. Owens2,
- Jerome Ricard3,
- Di Wu1,
- Tatiana Saltos1,
- Eileen Collyer1,
- Shaoping Hou1,
- John R. Bethea3, and
- Veronica J. Tom1
- 1Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129,
- 2Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, and
- 3Department of Biology, Drexel University, Philadelphia, Pennsylvania 19104
Author contributions
Author contributions: P.O.-O., J.R.B., and V.J.T. designed research; E.M., P.O.-O., V.B.-R., R.F., E.A.O., J.R., D.W., T.S., and E.C. performed research; S.H. contributed unpublished reagents/analytic tools; E.M., P.O.-O., V.B.-R., R.F., D.W., T.S., and V.J.T. analyzed data; E.M., P.O.-O., V.B.-R., R.F., J.R.B., and V.J.T. wrote the paper.
Disclosures
- Received August 22, 2017.
- Revision received March 8, 2018.
- Accepted March 14, 2018.
This work was supported by National Institutes of Health Grant R01 NS085426 to V.J.T., Department of Defense Congressionally Directed Medical Research Program Grant W81XWH-14-1-0605 to V.J.T., National Institutes of Health Grant R01 NS1069080 to V.J.T. and J.R.B., Craig H. Neilsen Foundation Grant 382566 to V.J.T., National Institutes of Health Grant R01 NS051709 to J.R.B., National Institutes of Health Grant R01 HL139754 to P.O.-O., American Heart Association Scientist Development Grant 16SDG27260276 to P.O.-O., Margaret Q. Landenberger Foundation Grant 002745 to P.O.-O., and Drexel University Dean's Fellowship for Excellence in Collaborative or Themed Research Training to E.M. We thank Dr. David E. Szymkowski (Xencor) for supplying XPro1595; Dr. Alexander G. Rabchevsky for providing the MATLAB algorithm that served as the basis for what we used to analyze the naturally occurring events; Dr. Vladimir Zhukarev for assistance with the confocal microscope; and the Drexel University Spinal Cord Research Center for use of its core facilities.
The authors declare no competing financial interests.
- Correspondence should be addressed to either of the following: Dr. John R. Bethea, Department of Biology, Drexel University, 3245 Chestnut Street, Philadelphia, PA 19104, jrb445{at}drexel.edu; or Dr. Veronica J. Tom, Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, veronica.tom{at}drexelmed.edu
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